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Correlation between serum vitamin D level and acute invasive enteritis in children
Lingrong Yang1, Yu Fang2, Jinyu Zheng2
1Sichuan Provincial Maternity and Child Health Care Hospital, Women and Children's Hospital of Chengdu Medical College, Chengdu, Sichuan, China.
Insights
Children with acute invasive enteritis had lower vitamin D levels. Ensuring adequate vitamin D through supplementation and outdoor activity may help prevent this common childhood illness.
Area of Science:
- Pediatrics
- Nutritional Immunology
- Infectious Diseases
Background:
- Diarrhea is a major global child mortality cause.
- Vitamin D deficiency compromises pathogen clearance and intestinal barrier function.
- Vitamin D deficiency exacerbates intestinal inflammation.
Purpose of the Study:
- To investigate the association between serum vitamin D levels and acute invasive enteritis in children.
- To identify risk factors for invasive enteritis in young children.
Main Methods:
- Prospective cohort study of 82 children (1-3 years) with acute invasive enteritis and 80 healthy controls.
- Collected fecal and blood samples for routine tests, C-reactive protein, and 25-hydroxyvitamin D (25-OHD) levels.
- Utilized multifactorial logistic regression to analyze influencing factors.
Main Results:
- Children with invasive enteritis had significantly lower serum 25-OHD levels (27.95 ± 9.91 ng/mL) compared to controls (32.76 ± 10.23 ng/mL).
- Lower rates of regular vitamin D supplementation and reduced outdoor activity duration were observed in the study group.
- Multivariate analysis revealed exclusive breastfeeding, increased outdoor activity, and regular vitamin D supplementation were associated with reduced invasive enteritis risk.
Conclusions:
- Low serum 25-OHD levels are associated with acute invasive enteritis in children aged 1-3 years.
- Consistent vitamin D supplementation and adequate outdoor activity may offer protection against invasive enteritis.
Background:
Diarrhea is a leading cause of death in young children worldwide. Vitamin D deficiency impairs the body's ability to clear pathogens, reduces tight junction protein expression in intestinal epithelial cells, and enhances Th1-mediated intestinal inflammation. This study aimed to investigate the effects of serum vitamin D levels on acute invasive enteritis in children.
Methods:
This prospective cohort study included 82 children aged 1-3 years with clinically diagnosed acute invasive enteritis at Sichuan Maternal and Child Health Hospital from February 2021 to February 2022, alongside a control group of 80 healthy children. Fecal specimens were collected for routine tests and occult blood analysis, while blood samples were taken for routine tests, C-reactive protein, and 25-OHD levels. Comparative analyses were performed between groups, and multifactorial logistic regression was used to identify factors influencing invasive enteritis.
Results:
The study group showed significantly lower serum 25-OHD levels (27.95 ± 9.91 ng/mL) compared to controls (32.76 ± 10.23 ng/mL, p < .01). Among the study group, 19.5% (16/82) had levels <20 ng/mL, versus 12.5% (10/80) in controls. Regular vitamin D supplementation was lower in the study group (58.5% vs. 77.5%, p < .05). Outdoor activity duration was also reduced (2.57 ± 0.98 h vs. 3.04 ± 0.88 h, p < .01). Multivariate analysis identified that exclusive breastfeeding, greater outdoor activity time and regular vitamin D supplementation were all associated with reduced risk of invasive enteritis (p < .05).
Conclusion:
The findings indicate an association between low serum 25-OHD levels and acute invasive enteritis in children aged 1-3 years, suggesting that consistent vitamin D supplementation and sufficient outdoor activity may protect against this condition.
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