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Discovery of VU6016235: A Highly Selective, Orally Bioavailable, and Structurally Distinct Tricyclic M4 Muscarinic

Julie L Engers1,2, Logan A Baker1,2, Sichen Chang1,2

  • 1Warren Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, Tennessee 37232, United States.

ACS Chemical Neuroscience
|September 24, 2024
PubMed

Keywords:
Alzheimer’s diseaseMuscarinic acetylcholine receptor (mAChR)Muscarinic acetylcholine receptor subtype 4 (M4)Parkinson’s diseasePositive allosteric modulator (PAM)SchizophreniaStructure−activity relationship (SAR)

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