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Related Experiment Video

Updated: Jun 12, 2025

Fluorescence Lifetime Macro Imager for Biomedical Applications

Fluorescence Lifetime Macro Imager for Biomedical Applications

Published on: April 7, 2023

BLEscope: A Bluetooth Low Energy (BLE) Microscope for Wireless Multicontrast Functional Imaging.

Subhrajit Das, Janaka Senarathna, Yunke Ren

IEEE Transactions on Bio-Medical Engineering

|September 24, 2024

Summary

This summary is machine-generated.

Researchers developed BLEscope, a wireless microscope using a low-power system-on-chip, for advanced neuroimaging. This innovation enables untethered, low-power functional imaging in small animals, advancing preclinical and clinical applications.

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Last Updated: Jun 12, 2025

Fluorescence Lifetime Macro Imager for Biomedical Applications

Fluorescence Lifetime Macro Imager for Biomedical Applications

Published on: April 7, 2023

Lensless Fluorescent Microscopy on a Chip

Lensless Fluorescent Microscopy on a Chip

Published on: August 17, 2011

Wide-field Fluorescent Microscopy and Fluorescent Imaging Flow Cytometry on a Cell-phone

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Published on: April 11, 2013

Area of Science:

Biomedical Engineering
Neuroimaging Technology
Wireless Sensor Systems

Background:

Advancements in low-power wireless systems (SoCs) drive IoT applications.
Growing need for lightweight, untethered, low-power neuroimaging systems for small animals.

Purpose of the Study:

Explore using low-power asset monitoring systems for wireless functional imaging.
Develop a novel architecture for fluorescence and hemodynamic contrast imaging.
Create a wireless microscope for in vivo applications.

Main Methods:

Integrated a Bluetooth Low Energy (BLE) 5.2 SoC with a CMOS image sensor.
Developed a multicontrast optical front-end (fluorescence and intrinsic optical signal channels).
Established a BLE protocol for remote operation and in vivo image acquisition at 1 fps.

Main Results:

Created 'BLEscope', a wireless microscope.
Achieved a benchmark of ~1.5 hours of continuous wireless imaging on a 100 mAh battery.
Successfully imaged fluorescent tracers, brain tumor cells, and blood vessel responses in vivo.

Conclusions:

BLEscope demonstrates feasibility for low-power wireless functional imaging.
Miniaturized versions could lead to implantable or wireless microscopes.
Potential to transform preclinical and clinical neuroimaging.