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Isolation and Th17 Differentiation of Naïve CD4 T Lymphocytes
Published on: September 26, 2013
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Interpreting the Function of the IL-23/IL-17 Axis through Bioinformatics
Sonia Isela Vazquez-Jimenez1,2, Grecia Denisse Gonzalez-Sanchez1, Celia Guerrero-Velazquez2
1Doctorado en Biociencias, Centro Universitario de Los Altos, Universidad de Guadalajara, Tepatitlán de Morelos, Jalisco, México.
Endocrine, Metabolic & Immune Disorders Drug Targets
|September 25, 2024
Summary
The IL-23/IL-17A axis and its co-expressed genes are linked to inflammatory and autoimmune diseases. Further research may reveal therapeutic targets for these conditions.
Area of Science:
- Bioinformatics
- Immunology
- Genetics
Background:
- The IL-23/IL-17A axis plays a crucial role in immune responses.
- Understanding its function and disease associations is vital for medical research.
Purpose of the Study:
- To identify central genes co-expressed within the IL-23/IL-17A axis and its receptors.
- To elucidate the functional ontology and modifying factors of these genes.
Main Methods:
- Utilized COXPRESdb for co-expressed gene identification.
- Employed ShinyGO and ToppGene for functional enrichment analysis.
- Applied NetworkAnalyst 3.0 for gene expression profiling.
Main Results:
- Genes in the IL-23/IL-17A axis primarily respond to microbial stimuli and inflammatory processes.
- These genes are significantly associated with various inflammatory and autoimmune diseases.
- Observed potential links to Behcet's disease, Graft-versus-host disease, and Hodgkin's disease.
Conclusions:
- The IL-23/IL-17A axis is implicated in multiple inflammatory and autoimmune pathologies.
- Further investigation is warranted to confirm its role and explore therapeutic potential.
- The IL-23/IL-17A axis presents a promising avenue for future therapeutic strategies.
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