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Revealing alterations in heart rate fluctuations during the progression of Chagas disease

Magdalena M Defeo1, Laura A Delaplace2, Juan C Goin3

  • 1Hospital Interzonal General de Agudos "Prof. R. Rossi", La Plata, Argentina.

Frontiers in Medicine
|September 25, 2024
PubMed

Insights

Heart rate variability (HRV) analysis using the false nearest neighbors index (FN10) can detect changes in Chagas disease progression. This index shows potential as a prognostic biomarker for heart disease in affected individuals.

Area of Science:

  • Cardiology
  • Biomedical Engineering
  • Complex Systems

Background:

  • Heart rate variability (HRV) reflects sinoatrial node (SAN) architecture and autonomic nervous system (ANS) regulation.
  • Chagas disease significantly impacts HRV, altering its complexity.
  • Understanding HRV changes is crucial for managing Chagas disease progression.

Purpose of the Study:

  • To evaluate the false nearest neighbors index (FN10) as a measure of HRV changes in Chagas disease.
  • To assess FN10's ability to reflect disease progression.
  • To identify potential prognostic biomarkers for Chagas heart disease.

Main Methods:

  • Retrospective, descriptive, cross-sectional study design.
  • Analysis of HRV time series in participants with Chagas disease.
  • Determination of FN10 dependence on age and sex in healthy individuals.

Main Results:

  • FN10 exhibits age-dependent scaling in healthy populations, independent of sex.
  • Elevated FN10 values were observed in some individuals with Chagas disease.
  • Findings correlate with pathophysiological mechanisms of Chagas disease progression.

Conclusions:

  • The FN10 index shows promise in reflecting HRV alterations in Chagas disease.
  • FN10 may serve as a candidate prognostic biomarker for heart disease in Chagas patients.
  • Further research can validate FN10 for clinical application in Chagas disease management.
Abstract

Keywords:
Chagas diseaseautonomic nervous systemfibrosisheart rate variabilitysinoatrial node

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