New Sulfurated Butyrolactones from the Fungus Penicillium janthinellum

Deep-sea derived fungi are considered as significant resources to discovery structurally diverse and biologically active natural compounds. In this study, four new sulfurated butyrolactones, penijanthiones A-D (1-4), together with four known analogues (5-8), were isolated from a Mariana Trench-derived fungus Penicillium janthinellum SH0301. Compounds 1-4 were the undescribed examples for natural butyrolactones coupling with a mercaptolactate moiety. Their structures including the absolute configurations of these new compounds were elucidated by comprehensive spectroscopic data, and calculated electronic circular dichroism (ECD). The plausible biosynthetic pathway of sulfur-incorporation of 1-4 was proposed. All of these isolated compounds were evaluated their cytotoxic, antimicrobial and antiviral activities.