Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Skin Cancer

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...

The Retinoblastoma Gene

The Retinoblastoma Gene

Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Recurrent Eyelid Ptosis as an Atypical Manifestation of Conjunctival Lymphoma.

The Journal of craniofacial surgery·2026

Same author

Artificial Intelligence in Ocular Oncology: Differentiating Choroidal Melanocytic Lesions.

Ophthalmology science·2025

Same author

Genomic Profiling of Intraocular Leiomyomas Reveals Recurrent Copy Number Alterations.

Translational vision science & technology·2025

Same author

Diagnostic accuracy of the non-compliance of the ISNT rule in glaucoma: Systematic review and meta-analysis.

European journal of ophthalmology·2025

Same author

Trial to compare mixed-use (multi-use and single-use) intermittent catheter management with single-use management over 12 months (The MultICath Trial): protocol for a non-inferiority randomised controlled trial.

BMJ open·2024

Same author

Invasive Treatment Strategy for Older Patients with Myocardial Infarction.

The New England journal of medicine·2024

Search research articles

Related Experiment Video

Updated: Jun 12, 2025

Author Spotlight: Anterior HR-OCT as a Non-Invasive Tool for Characterizing Ocular Surface Squamous Neoplasia

Author Spotlight: Anterior HR-OCT as a Non-Invasive Tool for Characterizing Ocular Surface Squamous Neoplasia

Published on: August 9, 2024

Pleomorphic Sarcoma, an Atypical Conjunctival Tumor.

Alvaro Ortiz¹, Emmanuel Vázquez², Carol Shields³

¹Anterior Segment Department, Aljaorza Specialized Center in Ophthalmology Ecuador.

The Journal of Craniofacial Surgery

|September 25, 2024

Summary

This summary is machine-generated.

This case report details an undifferentiated pleomorphic sarcoma, a rare conjunctival tumor. Diagnosis via biopsy led to enucleation of the affected eye.

More Related Videos

Author Spotlight: Genetically Engineered Mouse Models and Pathological Characterization of Neurofibromatosis Type 1 Associated Tumors

Author Spotlight: Genetically Engineered Mouse Models and Pathological Characterization of Neurofibromatosis Type 1 Associated Tumors

Published on: May 17, 2024

Implantation and Evaluation of Melanoma in the Murine Choroid via Optical Coherence Tomography

Implantation and Evaluation of Melanoma in the Murine Choroid via Optical Coherence Tomography

Published on: December 2, 2022

Related Experiment Videos

Last Updated: Jun 12, 2025

Author Spotlight: Anterior HR-OCT as a Non-Invasive Tool for Characterizing Ocular Surface Squamous Neoplasia

Author Spotlight: Anterior HR-OCT as a Non-Invasive Tool for Characterizing Ocular Surface Squamous Neoplasia

Published on: August 9, 2024

Author Spotlight: Genetically Engineered Mouse Models and Pathological Characterization of Neurofibromatosis Type 1 Associated Tumors

Author Spotlight: Genetically Engineered Mouse Models and Pathological Characterization of Neurofibromatosis Type 1 Associated Tumors

Published on: May 17, 2024

Implantation and Evaluation of Melanoma in the Murine Choroid via Optical Coherence Tomography

Implantation and Evaluation of Melanoma in the Murine Choroid via Optical Coherence Tomography

Published on: December 2, 2022

Area of Science:

Ophthalmology
Oncology
Pathology

Background:

Sarcomas are rare mesodermal connective tissue malignancies.
Undifferentiated pleomorphic sarcoma is an uncommon orbital tumor, representing less than 1% of cases.
This specific subtype lacks clear classification criteria by the World Health Organization.

Observation:

An 82-year-old male presented with a progressive conjunctival mass.
Symptoms included eye enlargement, redness, discharge, and foreign body sensation.
Biopsy was performed due to the lesion's biomicroscopic appearance.

Findings:

Histopathology and immunohistochemistry confirmed undifferentiated pleomorphic sarcoma.
The tumor did not meet established World Health Organization classification criteria.
The patient was blind in the affected eye due to glaucoma.

Implications:

This case highlights the importance of considering rare orbital tumors.
Prompt diagnosis and surgical intervention, such as enucleation, are crucial for management.
Further research may clarify diagnostic criteria for this sarcoma subtype.