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Updated: May 20, 2026

Cheek Injection Model for Simultaneous Measurement of Pain and Itch-related Behaviors

Cheek Injection Model for Simultaneous Measurement of Pain and Itch-related Behaviors

Published on: September 27, 2019

Mouse Models of Itch.

Daniel Yassky¹, Brian S Kim¹

¹Kimberly and Eric J. Waldman Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York, New York, USA; Allen Discovery Center for Neuroimmune Interactions, New York, New York, USA; Marc and Jennifer Lipschultz Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA; Mark Lebwohl Center for Neuroinflammation and Sensation, Icahn School of Medicine at Mount Sinai, New York, New York, USA; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA; Department of Immunology and Immunotherapy, Icahn School of Medicine at Mount Sinai, New York, New York, USA.

The Journal of Investigative Dermatology

|September 25, 2024

Summary

This summary is machine-generated.

Murine models are crucial for understanding itch mechanisms. This research guides scientists in using acute and chronic itch models to advance therapeutics for human pruritus.

Keywords:

Itch MRGPRX2 Mast cells Methods and Techniques for Skin Research Pruriceptor Pruritus

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Area of Science:

* Immunology
* Dermatology
* Neuroscience

Background:

* Murine models are essential preclinical tools for investigating the biological mechanisms of itch.
* Understanding the nuances between acute and chronic itch is critical for therapeutic development.

Purpose of the Study:

* To explore how murine models have advanced the understanding of itch mechanisms.
* To provide detailed protocols and experimental setups for itch research using mouse models.
* To differentiate between pruritogens and stimuli causing pruritogen release, and acute versus chronic itch models.

Main Methods:

* Review and synthesis of existing literature on murine models of itch.
* Development of detailed protocols for specific acute and chronic itch models.
* Comparative analysis of murine models in recapitulating human pruritus.

Main Results:

* Murine models effectively elucidate the complex mechanisms underlying both acute and chronic itch.
* Clear distinctions are established between direct pruritogens and indirect stimuli, as well as acute and chronic itch paradigms.
* Mouse models accurately reflect key aspects of human pruritus, aiding translational research.

Conclusions:

* Murine models have significantly transformed the comprehension of itch pathophysiology.
* These models are instrumental in the development of novel therapeutics for chronic pruritus.
* Standardized protocols enhance the reliability and reproducibility of itch research in mice.