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Updated: Jun 12, 2025

Facile Preparation of 2Z,4E-Dienamides by the Olefination of Electron-deficient Alkenes with Allyl Acetate
Published on: June 21, 2017
Cobalt-Catalyzed Synthesis of Alkenyl Heterocycles via Regioselective Intramolecular 1,4-Hydrofunctionalization of
Chi-Fan Zhu1, Yuan Tian1, Jun-Ju Mai1
1School of Pharmacy, Changzhou University, Changzhou, Jiangsu 213164, China.
Abstract:
We report a novel cobalt-catalyzed intramolecular 1,4-hydrofunctionalization of dienes. The reaction proceeds under mild conditions and is amenable to N- and O-nucleophiles. The protocol exhibits exclusive regioselectivity, yielding a number of different alkenyl heterocycles, including but not limited to dihydroisobenzofurans, isochromanes, tetrahydrofurans, morpholines, lactones, and isoindolines. Experimental studies were performed to offer some insight into the different mechanistic pathways and to rationalize the regio- and stereoselectivities of the reaction.
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