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The Rh phenotype r'r' in Polynesians.

C J Lyne, P L Clark, M A Lyne

    Human Heredity
    |January 1, 1985
    PubMed
    Summary
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    The r

    Area of Science:

    • * Hematology and Immunology
    • * Population Genetics
    • * Blood Group Serology

    Background:

    • * The r'r' (Cde/Cde) phenotype is a rare Rh blood group.
    • * Previous detections were primarily among Maori and Pacific Islander populations.
    • * Limited serological data exists for the Polynesian r' variant.

    Purpose of the Study:

    • * To conduct detailed serological investigations on 11 r'r' blood samples.
    • * To determine the serological characteristics of the Polynesian r' phenotype.
    • * To investigate potential relationships between Polynesian r' and other Rh variants.

    Main Methods:

    • * Detailed serological testing of 11 r'r' blood samples.
    • * Investigation for the presence of the Du antigen.

    Related Experiment Videos

  • * Comparative analysis with Negroid r' variants.
  • * Testing for high- and low-frequency blood group antigens.

    • Main Results:

    • * No evidence of the Du antigen was found in the tested samples.
    • * No serological relationship was identified between Polynesian r' and Negroid r'.
    • * The r' (Cde) phenotype in Polynesians is hypothesized to originate from a CDe mutation.
    • * No morphological abnormalities were observed in r'r' red blood cells.
    • * One sample exhibited the r'r' Jk(a-b-) phenotype.

    Conclusions:

    • * The Polynesian r' phenotype is distinct and likely arose from a CDe mutation.
    • * The r'r' phenotype does not present with morphological red cell abnormalities.
    • * Further research is warranted to understand the genetic basis and prevalence of rare blood group phenotypes in diverse populations.