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Related Experiment Video

Updated: Jun 12, 2025

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Aptamer biosensors for thrombin.

Zahra Oushyani Roudsari1, Hassan Ghasemi2, Seyyed Hossein Khatami3

  • 1Department of Medical Biotechnology, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran.

Clinica Chimica Acta; International Journal of Clinical Chemistry
|September 25, 2024
PubMed
Summary

Aptasensors offer enhanced detection of thrombin, a key biomarker for diseases like cancer and heart disease. This review covers recent advancements in optical, SERS, electrochemical, piezoelectric, and lateral flow aptasensor technologies for rapid point-of-care testing.

Keywords:
AptasensorsBiomarkerDetection mechanismsPoint-of-care testingThrombin

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Area of Science:

  • Biochemistry
  • Biomarker Detection
  • Biosensor Technology

Background:

  • Thrombin is a critical coagulation factor and a significant biomarker for diseases such as cancer and heart disease.
  • Accurate and rapid detection of thrombin is essential for disease prognosis, diagnosis, and monitoring.
  • Point-of-care testing (POCT) demands sensitive and efficient diagnostic tools.

Purpose of the Study:

  • To review recent advancements in aptasensor development for thrombin detection.
  • To explore various detection mechanisms employed in thrombin aptasensors.
  • To highlight the potential of aptasensors for improved biomarker analysis.

Main Methods:

  • Literature review of recent studies on aptasensors for thrombin detection.
  • Categorization of aptasensors based on detection principles: optical, SERS, electrochemical, piezoelectric, and lateral flow assays.
  • Analysis of aptamer implementation for enhanced target recognition.

Main Results:

  • Aptasensors demonstrate improved target recognition and detection capabilities for thrombin.
  • Diverse detection mechanisms, including optical, SERS, electrochemical, piezoelectric, and lateral flow, have been successfully applied.
  • Recent studies show significant progress in developing sensitive and rapid thrombin detection methods.

Conclusions:

  • Aptasensors represent a promising platform for sensitive and specific thrombin detection.
  • The integration of aptamers significantly enhances the performance of biosensors.
  • Continued research in aptasensor technology will advance POCT for critical biomarker monitoring.