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Patent Foramen Ovale and Hypoxemia.

Ashley Nguyen1, Elaine Nguyen2, Preetham Kumar3

  • 1Department of Medicine, Cleveland Clinic Florida, 2950 Cleveland Clinic Boulevard, Weston, FL 33331, USA.

Cardiology Clinics
|September 25, 2024
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Summary
This summary is machine-generated.

A patent foramen ovale (PFO) is linked to stroke and migraines, but also less common conditions like platypnea-orthodeoxia syndrome and sleep apnea. This review explores these PFO-associated conditions.

Keywords:
Chronic bronchitisChronic obstructive pulmonary diseaseEmphysemaObstructive sleep apneaPatent foramen ovalePlatypnea-orthodeoxia syndrome

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Area of Science:

  • Cardiology
  • Pulmonology
  • Neurology

Background:

  • A patent foramen ovale (PFO) is an atrial septal defect present in adults.
  • While commonly associated with cryptogenic stroke and migraine with aura, PFO has other clinical implications.

Purpose of the Study:

  • To discuss and summarize literature on less common conditions associated with PFO.
  • To explore the link between PFO and platypnea-orthodeoxia syndrome, obstructive sleep apnea, and COPD with disproportionate hypoxemia.

Main Methods:

  • Literature review of studies examining PFO and associated conditions.
  • Synthesis of findings related to clinical manifestations and pathophysiology.

Main Results:

  • PFO is implicated in platypnea-orthodeoxia syndrome, characterized by respiratory distress when upright.
  • PFO is also associated with obstructive sleep apnea and hypoxemia in COPD patients.

Conclusions:

  • PFO presents with a spectrum of clinical manifestations beyond stroke and migraine.
  • Understanding these associations is crucial for comprehensive patient management.