TRIVALVE Score: A Risk Score for Mortality/Hospitalization Prediction in Patients Undergoing Transcatheter Tricuspid...

Area of Science:

• Cardiology
• Interventional Cardiology
• Health Outcomes Research

Background:

• Transcatheter tricuspid valve intervention (TTVI) is increasingly used for tricuspid regurgitation (TR).
• No established risk stratification exists for patients undergoing TTVI.

Purpose of the Study:

• To develop a dedicated risk score for patients with severe TR undergoing TTVI.
• To aid heart teams in selecting optimal therapies for these patients.

Main Methods:

• The score was derived from the TRIVALVE registry (NCT03416166).
• A stepwise logistic regression model predicted 12-month mortality or rehospitalization.
• Internal validation included ROC curve analysis and bootstrapping.

Main Results:

• The study included 483 patients; 19% experienced 12-month mortality or rehospitalization.
• The final risk score incorporates atrial fibrillation, low GFR, elevated liver enzymes, right heart failure, and reduced LVEF.
• The score demonstrated moderate discrimination (AUC 68%).

Conclusions:

• A novel, simple risk score is proposed for TTVI candidates.
• This tool can assist heart teams in personalized therapy selection for severe TR.