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Dorthe B Berthelsen1,2,3, Linea Rishøj Thorlacius1,4,5,6, Bente Villumsen4,7

  • 1Parker Instituttet, Københavns Universitetshospital - Bispebjerg og Frederiksberg Hospital.

Ugeskrift for Laeger
|September 26, 2024
PubMed
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A core outcome set (COS) standardizes essential outcomes for clinical trials. This ensures consistent data collection and reporting across studies for better disease and population research.

Area of Science:

  • Clinical Trials Methodology
  • Health Outcomes Research
  • Standardization in Medicine

Background:

  • Clinical trials require consistent outcome measurement for reliable comparisons.
  • A core outcome set (COS) provides a standardized minimum set of outcomes.
  • Current practices lack global consensus on essential outcome domains.

Purpose of the Study:

  • To define the concept and importance of a core outcome set (COS).
  • To highlight the necessity of global consensus in outcome domain selection for clinical trials.
  • To emphasize the subsequent need for standardized measurement instruments and interpretation.

Main Methods:

  • This review synthesizes existing literature on core outcome sets.
  • It examines the principles and application of COS in clinical research.

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  • The review discusses the importance of consensus-building for outcome selection.

    • Main Results:

    • A core outcome set (COS) is a consensus-driven minimum set of outcomes for specific diseases or populations.
    • COS facilitates global agreement on essential outcome domains to be measured.
    • Defining what to measure is the first step; agreeing on how to measure is critical.

    Conclusions:

    • Core outcome sets are vital for standardizing clinical trial data.
    • Establishing consensus on outcome measurement instruments and interpretation is crucial.
    • Implementing COS improves the quality and comparability of research findings.