Mupirocin Ointment Effect on Polyposis Recurrence After Sinus Surgery

Area of Science:

• Otolaryngology
• Infectious Diseases
• Surgical Outcomes

Background:

• Staphylococcus aureus is a key pathogen implicated in the recurrence of symptoms for patients suffering from chronic rhinosinusitis with nasal polyps.
• Effective management strategies are crucial to reduce symptom recurrence and improve surgical outcomes in these patients.

Purpose of the Study:

• To investigate the efficacy of topical mupirocin ointment in the nasal vestibule for reducing symptom recurrence.
• To assess the impact of mupirocin on the efficiency of functional endoscopic sinus surgery outcomes.

Main Methods:

• A clinical trial was conducted involving patients with chronic rhinosinusitis, nasal polyps, and positive Staphylococcus aureus nasal cultures.
• Mupirocin ointment was applied to the right nostril (intervention), while vitamin A ointment was applied to the left nostril (control).
• Lund-Mackay radiological and Lund-Kennedy endoscopic scores were evaluated pre- and post-surgery.

Main Results:

• Over 90% of the 60 participants had positive Staphylococcus aureus nasal cultures.
• Both intervention and control groups showed significant improvement in radiological and endoscopic scores post-surgery (P<0.001).
• No significant difference in score improvement was observed between the mupirocin and vitamin A groups (P>0.56).

Conclusions:

• Nasal mupirocin application after endoscopic sinus surgery does not significantly reduce symptom recurrence in chronic rhinosinusitis with nasal polyps.
• The findings suggest that mupirocin is not an effective prophylactic agent for preventing Staphylococcus aureus-related symptom recurrence in this patient population.