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Pharmacovigilance

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Post-marketing surveillance is a critical component of pharmaceutical regulation, often uncovering unanticipated adverse drug reactions (ADRs) once a drug is widely used over an extended period.
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Drug Therapy01:28

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The advent of drug therapy has profoundly shaped modern mental health care, providing targeted treatments for a range of psychological disorders. Psychotherapeutic drugs, classified into antianxiety, antidepressant, and antipsychotic medications, address symptoms across anxiety disorders, mood disorders, and schizophrenia. While these medications have transformed patient outcomes, they require careful management due to their potential side effects and limitations.
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Drugs, the chemical agents used in diagnosing, treating, or preventing diseases, undergo a four-phase process of development: pharmaceutic, pharmacokinetics, pharmacodynamics, and therapeutic.
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Prescription drugs require a prescription from a medical practitioner and can only be obtained from a pharmacy. They have many applications, including treating pain, anxiety, and hypertension.
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Preclinical development consists of a series of tests that ensure the safety and efficacy of a new therapeutic compound before it is tested in humans. There are four main phases to this process. First, safety pharmacology tests are conducted to ensure the drug does not produce any acutely harmful effects. These tests examine parameters such as bronchoconstriction, cardiac dysrhythmias, blood pressure changes, and ataxia. Next, preliminary toxicological testing is performed to determine the...
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Drug regulation encompasses the management of drug usage by evaluating its safety and efficacy through assessments conducted by regulatory authorities. Regrettably, the history of drug regulation is marred by several catastrophic events. One such incident is the Elixir Sulfanilamide tragedy, in which the toxic compound diethyl glycol was included in a sweet-tasting medication, leading to numerous fatalities. This event prompted the enactment of the Food, Drug, and Cosmetic Act in 1938. Under...
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Practice-enhancing publications about the medication-use process in 2023.

Tyler A Vest1, Nicholas P Gazda2, Daniel P O'Neil3

  • 1University of Vermont Health Network, Burlington, VT, and University of North Carolina Eshelman School of Pharmacy, Chapel Hill, NC, USA.

American Journal of Health-System Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists
|September 26, 2024
PubMed
Summary
This summary is machine-generated.

This review highlights key 2023 literature impacting the medication-use process (MUP) in health-system pharmacy. It identifies 40 practice-enhancing articles across prescribing, dispensing, administration, and monitoring for improved patient care.

Keywords:
administrationcomputerized prescriber order entrydispensingmedication-use processmonitoringprescribing

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Area of Science:

  • Pharmacy Practice
  • Health Outcomes Research

Background:

  • The medication-use process (MUP) is critical for safe medication utilization in healthcare.
  • Continuous evaluation of MUP literature is essential for practice improvement.

Purpose of the Study:

  • To identify, prioritize, and summarize 2023 literature relevant to the medication-use process (MUP).
  • To assess the impact of identified literature on health-system pharmacy daily practice.

Main Methods:

  • Conducted a PubMed search and reviewed selected pharmacy journal tables of contents for 2023 publications.
  • Evaluated 5,314 articles for relevance to at least one component of the MUP (prescribing/transcribing, dispensing, administration, monitoring).

Main Results:

  • Identified 40 practice-enhancing articles from 5,314 reviewed.
  • Categorized articles: 8 on prescribing/transcribing, 15 on dispensing, 6 on administration, and 11 on monitoring.
  • Summarized trends and highlighted the importance of these findings for health-system pharmacy.

Conclusions:

  • Routine review of published literature is crucial for incorporating significant findings into daily practice.
  • This article provides a curated summary of impactful 2023 MUP literature.
  • Health-system pharmacists can leverage this information to drive practice changes and improve institutional medication safety.