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Related Concept Videos

Genomics02:02

Genomics

36.2K
Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
36.2K
Evolutionary Relationships through Genome Comparisons02:54

Evolutionary Relationships through Genome Comparisons

5.7K
Genome comparison is one of the excellent ways to interpret the evolutionary relationships between organisms. The basic principle of genome comparison is that if two species share a common feature, it is likely encoded by the DNA sequence conserved between both species. The advent of genome sequencing technologies in the late 20th century enabled scientists to understand the concept of conservation of domains between species and helped them to deduce evolutionary relationships across diverse...
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Genomic DNA in Eukaryotes00:58

Genomic DNA in Eukaryotes

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Eukaryotes have large genomes compared to prokaryotes. To fit their genomes into a cell, eukaryotic DNA is packaged extraordinarily tightly inside the nucleus. To achieve this, DNA is tightly wound around proteins called histones, which are packaged into nucleosomes that are joined by linker DNA and coil into chromatin fibers. Additional fibrous proteins further compact the chromatin, which is recognizable as chromosomes during certain phases of cell division.
46.8K
Genome Annotation and Assembly03:36

Genome Annotation and Assembly

18.8K
The genome refers to all of the genetic material in an organism. It can range from a few million base pairs in microbial cells to several billion base pairs in many eukaryotic organisms. Genome assembly refers to the process of taking the DNA sequencing data and putting it all back together in a correct order to create a close representation of the original genome. This is followed by the identification of functional elements on the newly assembled genome, a process called genome annotation.
18.8K
Genomic DNA in Prokaryotes00:46

Genomic DNA in Prokaryotes

43.5K
The genome of most prokaryotic organisms consists of double-stranded DNA organized into one circular chromosome in a region of cytoplasm called the nucleoid. The chromosome is tightly wound, or supercoiled, for efficient storage. Prokaryotes also contain other circular pieces of DNA called plasmids. These plasmids are smaller than the chromosome and often carry genes that confer adaptive functions, such as antibiotic resistance.
Genomic Diversity in Bacteria
Although bacterial genomes are much...
43.5K
Comparing Copy Number Variations and SNPs02:26

Comparing Copy Number Variations and SNPs

17.6K
Sequencing of the human genome has opened up several best-kept secrets of the genome. Scientists have identified thousands of genome variations that exist within a population. These variations can be a single nucleotide or a larger chromosomal variation.
Copy number variations or CNVs are the structural variations that cover more than 1kb of DNA sequence. The single nucleotide polymorphism (SNP), on the other hand, is a single nucleotide change or a point mutation that is found in more than 1%...
17.6K

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Related Experiment Video

Updated: Jun 12, 2025

Targeted Next-generation Sequencing and Bioinformatics Pipeline to Evaluate Genetic Determinants of Constitutional Disease
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Targeted Next-generation Sequencing and Bioinformatics Pipeline to Evaluate Genetic Determinants of Constitutional Disease

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Confusing Genomic Terms: The Importance of Being Precise.

Suzanne M Mahon1, Patricia Friend2, Susan Yackzan3

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Genomic science advances are revolutionizing cancer care. Understanding fundamental genomic concepts is crucial for effective cancer prevention, surveillance, and treatment strategies.

Keywords:
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Area of Science:

  • Genomic Science
  • Oncology
  • Cancer Care

Background:

  • Genomic science has rapidly advanced.
  • These advancements have direct implications for cancer patient care.
  • Foundational knowledge is essential for understanding modern oncology.

Purpose of the Study:

  • To highlight the impact of genomic science on cancer care.
  • To emphasize the necessity of understanding basic genomic concepts.
  • To provide a rationale for current cancer prevention, surveillance, and treatment.

Main Methods:

  • Review of current genomic science literature.
  • Analysis of the impact of genomics on clinical oncology.
  • Synthesis of foundational concepts relevant to cancer care.

Main Results:

  • Genomic advancements are transforming cancer prevention.
  • Genomic understanding is key to effective cancer surveillance.
  • Personalized treatment strategies are driven by genomic insights.

Conclusions:

  • Mastery of genomic science is indispensable for healthcare professionals.
  • A strong grasp of genomics improves patient outcomes in oncology.
  • Genomic knowledge underpins the future of cancer management.