Related Experiment Video
Updated: Jul 22, 2026
In Vivo Multimodal Imaging and Analysis of Mouse Laser-Induced Choroidal Neovascularization Model
Published on: January 21, 2018
MACULAR VOLUME SCAN AS A MARKER OF ANGIOGRAPHIC UVEITIC RETINAL VASCULITIS: A Retrospective Longitudinal Study
Akhila Alapati1, Saleema Kherani1, Tedi Begaj1,2
1Department of Ophthalmology, Northwestern University Feinberg School of Medicine, Chicago, Illinois; and.
Purpose:
To determine whether optical coherence tomography thickness values from macular volume scans can be used to detect uveitic retinal vasculitis.
Methods:
Retrospective study of patients with noninfectious retinal vasculitis. Fluorescein angiogram and 61-line optical coherence tomography macular volume scans with an overlying Early Treatment Diabetic Retinopathy study grid were obtained. Correlation between 1 mm and 6 mm Early Treatment Diabetic Retinopathy study ring values and posterior pole vasculitis was analyzed. A linear longitudinal model was used to assess the relationship between global retinal vasculitis scores and optical coherence tomography macular thickness parameters.
Results:
Ninety-nine eyes of 54 patients were included. A total of 460 optical coherence tomography and fluorescein angiogram pairs were analyzed. Central (1 mm) macular thickness was weakly correlated with posterior pole vasculitis (correlation coefficient [rho] = 0.09, P = 0.06). Both the mean 6 mm ring (rho = 0.11, P = 0.018) and the average of the superior and inferior (S/I) 6 mm ring values (rho = 0.13, P = 0.006) were strongly correlated with posterior pole leakage. The longitudinal model showed that S/I 6 mm ring values are associated with vasculitis in the posterior pole, mid, and far periphery ( P < 0.0001).
Conclusion:
Optical coherence tomography-based macular volume thickness can detect uveitic retinal vasculitis and aid in monitoring disease activity.
