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Thyroid function, physical activity and sedentary behaviour: A bidirectional two-sample Mendelian randomisation

Chenyu Zhang1, Yutong Han1, Xiaotong Gao2

  • 1Department of Endocrinology and Metabolism, Institute of Endocrinology, NHC Key Laboratory of Diagnosis and Treatment of Thyroid Diseases, The First Hospital of China Medical University, Shenyang, Liaoning, China.

Journal of Global Health
|September 26, 2024
PubMed
Summary
This summary is machine-generated.

Higher thyroid stimulating hormone (TSH) levels causally increase leisure screen time (LST), indicating thyroid function influences physical activity. Body mass index (BMI) did not mediate this relationship.

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Area of Science:

  • Endocrinology
  • Genetics
  • Public Health

Background:

  • The relationship between thyroid function and physical activity (PA) is not well understood.
  • Thyroid hormones, including thyroid stimulating hormone (TSH) and free thyroxine (FT4), play crucial roles in metabolism and energy expenditure.
  • Daily PA, encompassing leisure screen time (LST) and moderate-to-vigorous physical activity (MVPA), significantly impacts overall health.

Purpose of the Study:

  • To investigate the causal relationship between genetically proxied thyroid-related traits and daily PA measures.
  • To determine if thyroid function influences PA or vice versa.
  • To explore the potential mediating role of body mass index (BMI) in this relationship.

Main Methods:

  • Utilized bidirectional two-sample Mendelian randomization (MR) analysis.
  • Employed genome-wide association study (GWAS) data for thyroid traits and PA measures.
  • Applied inverse variance weighted (IVW) method with sensitivity analyses (MR-Egger, weighted median, MR-PRESSO) and multivariable MR (MVMR) incorporating BMI-related traits.

Main Results:

  • A significant positive causal effect was observed where increased genetically proxied TSH levels led to increased LST (β=0.040, P=9.776×10⁻⁵).
  • This association remained significant in MVMR analysis, even after accounting for BMI (MVMR-IVW: β=0.042, P=0.007).
  • No evidence suggested that PA causally influences thyroid function in either direction.

Conclusions:

  • Thyroid function, specifically TSH levels, causally influences daily PA, particularly increasing LST.
  • The observed TSH-LST association is independent of BMI.
  • These findings highlight a unidirectional causal link from thyroid function to physical activity patterns.