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In Situ Functionalization of Polar Polythiophene-Based Organic Electrochemical Transistor to Interface In Vitro

Sebastian Buchmann1,2,3, Pepijn Stoop1,2,3, Kim Roekevisch1,2,3

  • 1Division of Nanobiotechnology, Department of Protein Science, SciLifeLab, KTH Royal Institute of Technology, Stockholm 177 65, Sweden.

ACS Applied Materials & Interfaces
|September 27, 2024
PubMed
Summary

A new hydroxylated conjugated polymer, p(g42T-T)-8% OH, enables accumulation mode organic electrochemical transistors (OECTs) for improved biointerfacing. This material facilitates cell monitoring and surface modification for enhanced biological system interaction.

Keywords:
Caco-2OECTsOMIECSbio interfacecell barrierfunctionalized conjugated polymerin situ functionalization

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Area of Science:

  • Materials Science
  • Biotechnology
  • Organic Electronics

Background:

  • Organic mixed ionic-electronic conductors offer advantages over inorganic conductors for biological system interfacing.
  • Poly(3,4-ethylenedioxythiophene):polystyrenesulfonate (PEDOT/PSS) is a common material in organic bioelectronics but has limitations.
  • Existing organic electrochemical transistors (OECTs) often operate in depletion mode and lack functional groups for biointerfacing.

Purpose of the Study:

  • To introduce a novel thiophene-based conjugated polymer with tunable surface properties for biointerfacing.
  • To investigate the compatibility of ethylene glycol side chain-containing conjugated polymers with direct cell contact.
  • To demonstrate the utility of the new polymer in fabricating accumulation mode OECTs for biological monitoring.

Main Methods:

  • Synthesis of a new thiophene-based conjugated polymer, p(g42T-T)-8% OH, with 8% hydroxylated side chains.
  • Evaluation of the cytocompatibility of the conjugated polymer in direct contact with cells.
  • Fabrication of accumulation mode OECTs using p(g42T-T)-8% OH.
  • Monitoring of epithelial barrier formation in Caco-2 cells using the fabricated OECTs.

Main Results:

  • The conjugated polymer p(g42T-T)-8% OH demonstrates compatibility with direct cell contact.
  • The hydroxyl groups enable covalent surface modification, allowing control over cell adhesion.
  • Accumulation mode OECTs fabricated with p(g42T-T)-8% OH successfully monitored epithelial barrier formation in vitro.
  • The new polymer offers improved biointerfacing capabilities compared to traditional materials.

Conclusions:

  • p(g42T-T)-8% OH is a versatile conjugated polymer for advanced organic bioelectronics.
  • The material's tunable surface chemistry and accumulation mode operation are key for effective biointerfacing.
  • This work paves the way for developing next-generation organic electronic devices for biological monitoring and interfacing.