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Updated: Jun 12, 2025

Facile Preparation of 4-Substituted Quinazoline Derivatives
Published on: February 15, 2016
New Tricyclic Aryl Quinazoline Derivatives by Suzuki-Miyaura Cross-Coupling
Burkhon Elmuradov1,2, Rasul Okmanov2, Bakhromjon Juraev2
1Leibniz Universität Hannover, Institut für Organische Chemie, Schneiderberg 1B, D-30167, Hannover, Germany.
Abstract:
A number of new deoxyvasicinone (2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-one) and mackinazolinone (6,7,8,9-tetrahydro-11H-pyrido[2,1-b]quinazolin-11-one) derivatives with aryl substituents at C7/C8 and at C5 are reported. These compounds are rare representatives of their kind and were prepared in high yields by Suzuki-Miyaura cross-coupling reactions between 7-bromo-2,3-dihydro[2,1-b]quinazoline-9-(1H)-one, 5,7-dibromo-2,3-dihydro[2,1-b]quinazoline-9-(1H)-one or 8-bromomackinazolinone and respective arylboronic acids with palladium acetate as the catalyst. The products were characterized spectroscopically and, in addition, by X-ray crystal structure analyses in six cases.
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