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Updated: Jun 11, 2025

Implantation of the Syncardia Total Artificial Heart
Published on: July 18, 2014
Organizational challenges for partial heart transplantation
Vincent S Alexander1,2, Andrew D Vogel1,2, Zachary T Silvano1,2
1Department of Cardiovascular Surgery, Arkansas Children's Hospital, 1 Children's Way, Little Rock, AR 72202, USA.
Abstract:
Partial heart transplantation (PHT) has emerged as a new treatment strategy to correct unrepairable heart valve dysfunction in pediatric patients. PHT selectively replaces the dysfunctional components of the recipient's heart and spares the native ventricles. As a result, the transplant biology of PHTs differs from heart transplants. Notably, donor hearts that are unsuitable for whole heart transplantation can be used, graft preservation can be prolonged and immunosuppression levels can be lowered. These nuances of PHT transplant biology have important implications for organizational aspects of PHT clinical application.
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