Occlusive retinal vasculitis associated with intravitreal Faricimab injections

Area of Science:

• Ophthalmology
• Retinal Vascular Diseases
• Pharmacovigilance

Background:

• Intravitreal Faricimab (Vabysmo) is a novel bispecific antibody used for retinal diseases.
• Diabetic macular edema is a common complication of diabetes mellitus.
• Vascular occlusive events are a known, albeit rare, concern with intravitreal therapies.

Purpose of the Study:

• To report a case of occlusive vasculitis.
• To investigate a potential adverse event associated with intravitreal Faricimab (Vabysmo) injections.

Main Methods:

• Retrospective case report.
• Clinical presentation and diagnostic workup of a patient with vision loss post-Faricimab injection.

Main Results:

• A 52-year-old male developed sudden vision reduction, retinal hemorrhages, and vascular occlusions after Faricimab treatment for diabetic macular edema.
• Differential diagnoses were ruled out.
• The patient's condition stabilized with oral and intravitreal steroid therapy.

Conclusions:

• Occlusive vasculitis is a rare but potential complication of intravitreal Faricimab (Vabysmo) therapy.
• Further comprehensive reporting and analysis are crucial for understanding and managing this adverse event.