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Quantitative and Qualitative Examination of Particle-particle Interactions Using Colloidal Probe Nanoscopy
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The Particle Drifting Effect: A Combined Function of Colloidal and Drug Properties
Da Hye Yang1, Saeed Najafian1,2, Bodhisattwa Chaudhuri1,3,2
1Department of Pharmaceutical Sciences, University of Connecticut, 69 North Eagleville Road, Unit 3092, Storrs, Connecticut 06269, United States.
Molecular Pharmaceutics
|September 27, 2024
Summary
The particle drifting effect enhances drug absorption by overcoming boundary layer resistance. Its rate depends on particle properties and dissolution, impacting formulation development and bioavailability prediction.
Area of Science:
- Pharmaceutical Sciences
- Materials Science
- Biophysics
Background:
- Nanosized colloidal drug particles can enhance drug absorption by overcoming diffusional resistance.
- The particle drifting effect is gaining attention, but its mechanisms and predictive models are underdeveloped.
Purpose of the Study:
- To systematically evaluate factors influencing the particle drifting effect.
- To elucidate the mechanistic basis of particle drifting for improved drug delivery.
Main Methods:
- Biphasic diffusion experiments.
- Computational fluid dynamics (CFD) simulations.
- Mass transport analyses.
Main Results:
- Particle drifting involves sequential particle dissolution/dissociation followed by free drug absorption.
- The rate-limiting step (dissolution or absorption) dictates the effect's magnitude.
- Particle size, concentration, solubility, and bile salt interactions influence the effect.
Conclusions:
- The particle drifting effect is a dynamic process influenced by multiple factors.
- Understanding these dynamics is crucial for rational formulation design.
- This research aids in predicting bioavailability for colloidal particle formulations.
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