Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Three-Dimensional Microscopy in Microbiology01:28

Three-Dimensional Microscopy in Microbiology

Three-dimensional imaging techniques are essential in cell biology, allowing researchers to visualize intricate cellular structures with high resolution. Two prominent methods, Differential Interference Contrast Microscopy (DIC) and Confocal Scanning Laser Microscopy (CSLM), provide distinct advantages for imaging live and thick specimens, respectively.Differential Interference Contrast MicroscopyDIC microscopy enhances contrast in transparent, unstained samples by converting phase...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Rapid Nanocellulose Wet Nanoimprint Lithography for Tunable Structural Color.

ACS nano·2025
Same author

Tunable Electrokinetic Motion of Charged Nanoparticles in an Aqueous Solution Using Interdigitated Microelectrodes.

Nanomaterials (Basel, Switzerland)·2025
Same author

Improving transport efficiency for large human cells for enabling accurate determination of cellular nanoparticle uptake via SC-ICP-TOF-MS.

Talanta·2025
Same author

Investigating the Nanoscale Dynamics of <i>Chlorella vulgaris</i> Flocculation with Pyridinium-Modified Cellulose Nanocrystals.

Langmuir : the ACS journal of surfaces and colloids·2025
Same author

Quantitative DSC Assessment of the Polymorph-Specific Crystallinity of Poly(Lactic Acid) and the Impact of a Self-Assembling Nucleating Agent and PEG Plasticizer.

Polymers·2025
Same author

Laccase-Mediated Incorporation of Xylans and Lignin-Carbohydrate Complexes into High-Yield Eucalyptus Kraft Fibers.

ACS omega·2025
Same journal

DNAzyme-Enhanced CRISPR/Cas12a Cascade Enables Isothermal, One-Pot RNA Diagnostics.

ACS applied materials & interfaces·2026
Same journal

Continuous π-Conjugation in β-Ketoenamine Covalent Organic Frameworks Boosts Charge Transfer for Selective Photocatalysis.

ACS applied materials & interfaces·2026
Same journal

Scalable Ionogel-Based Thermochromic Smart Windows: Enhanced Solar Regulation, Weatherability, and Processability.

ACS applied materials & interfaces·2026
Same journal

Metal-Organic Framework Monoliths Derived from Emulsion-Templated Foams for Reactive Filtration.

ACS applied materials & interfaces·2026
Same journal

Binary to Quaternary Rare-Earth Phosphates: Compositional Effects on Thermal Properties and CMAS Corrosion Resistance of Environmental Barrier Coatings.

ACS applied materials & interfaces·2026
Same journal

Suture-Free Piezoelectric Band-Aid Membrane for Complex Peripheral Nerve Defects.

ACS applied materials & interfaces·2026
See all related articles

Related Experiment Video

Updated: Jun 16, 2026

3D Human Myocardial Tissue Generation Using Melt Electrospinning Writing of Polycaprolactone Scaffolds and hiPSC-Derived Cardiac Cells
06:17

3D Human Myocardial Tissue Generation Using Melt Electrospinning Writing of Polycaprolactone Scaffolds and hiPSC-Derived Cardiac Cells

Published on: March 28, 2025

370

Optically Active, Paper-Based Scaffolds for 3D Cardiac Pacing.

Fanglei Guo1, Stijn Jooken1, Amin Ahmad1

  • 1Laboratory for Soft Matter and Biophysics, Department of Physics and Astronomy, KU Leuven, 3001 Leuven, Belgium.

ACS Applied Materials & Interfaces
|September 27, 2024
PubMed
Summary
This summary is machine-generated.

Researchers developed a novel paper-based scaffold using gold nanorods and quantum dots for optical control of cardiac cells. This technology enables precise pacing and monitoring of engineered heart tissue via near-infrared light.

Keywords:
3D cardiac constructcardiomyocyte pacingpaper-based cell scaffoldplasmonic modulationquantum dot nanothermometer

More Related Videos

A Cardiac Microphysiological System for Studying Ca2+ Propagation via Non-genetic Optical Stimulation
08:29

A Cardiac Microphysiological System for Studying Ca2+ Propagation via Non-genetic Optical Stimulation

Published on: March 21, 2025

565
A Net Mold-based Method of Scaffold-free Three-Dimensional Cardiac Tissue Creation
06:57

A Net Mold-based Method of Scaffold-free Three-Dimensional Cardiac Tissue Creation

Published on: August 5, 2018

8.9K

Related Experiment Videos

Last Updated: Jun 16, 2026

3D Human Myocardial Tissue Generation Using Melt Electrospinning Writing of Polycaprolactone Scaffolds and hiPSC-Derived Cardiac Cells
06:17

3D Human Myocardial Tissue Generation Using Melt Electrospinning Writing of Polycaprolactone Scaffolds and hiPSC-Derived Cardiac Cells

Published on: March 28, 2025

370
A Cardiac Microphysiological System for Studying Ca2+ Propagation via Non-genetic Optical Stimulation
08:29

A Cardiac Microphysiological System for Studying Ca2+ Propagation via Non-genetic Optical Stimulation

Published on: March 21, 2025

565
A Net Mold-based Method of Scaffold-free Three-Dimensional Cardiac Tissue Creation
06:57

A Net Mold-based Method of Scaffold-free Three-Dimensional Cardiac Tissue Creation

Published on: August 5, 2018

8.9K

Area of Science:

  • Biomedical Engineering
  • Materials Science
  • Nanotechnology

Background:

  • Current methods for modulating cardiac cell activity, such as electrode-based or optogenetic approaches, have limitations in spatial resolution and compatibility with 3D constructs.
  • There is a need for advanced in vitro platforms for cardiac tissue engineering, drug screening, and disease modeling that offer precise control and monitoring capabilities.

Purpose of the Study:

  • To design and fabricate a light-addressable, paper-based nanocomposite scaffold for optical pacing and read-out of in vitro cardiac tissue.
  • To investigate the use of gold nanorods (GNRs) and quantum dots (QDs) for precise modulation and monitoring of cardiomyocyte activity.
  • To evaluate the potential of this platform as an alternative to existing methods for cardiac cell manipulation and tissue engineering.

Main Methods:

  • Fabrication of a nanocomposite scaffold using paper cellulose microfibers functionalized with GNRs and QDs, embedded in a collagen matrix.
  • Utilizing modulated near-infrared (NIR) laser illumination to induce local temperature gradients via GNRs for cardiomyocyte activity modulation.
  • Employing temperature-dependent QD photoluminescence (PL) for real-time reporting of local temperature changes and monitoring cellular responses.

Main Results:

  • The paper-based scaffold successfully facilitated the tubular organization of HL-1 cardiac muscle cells.
  • NIR plasmonic stimulation using GNRs enabled reversible modulation of cardiomyocyte activity.
  • The QD photoluminescence provided accurate read-out of temperature changes, correlating with cellular activity modulation.

Conclusions:

  • The developed paper-based nanocomposite scaffold offers a facile and scalable platform for optical pacing and read-out of cardiac tissue.
  • This NIR-based approach provides nanoscale spatial resolution and serves as a promising alternative to electrode-based or optogenetic methods.
  • The platform holds significant potential for advancing in vitro drug screening assays and developing more accurate models of heart disease.