Related Experiment Video

Updated: Jun 11, 2025

A Mouse 5/6th Nephrectomy Model That Induces Experimental Uremic Cardiomyopathy
07:52

A Mouse 5/6th Nephrectomy Model That Induces Experimental Uremic Cardiomyopathy

Published on: November 7, 2017

20.4K

Lactoferrin in Pediatric Chronic Kidney Disease and Its Relationship with Cardiovascular Risk

Chun-Yi Ho1,2, Pei-Chen Lu1, Wei-Ling Chen1

  • 1Department of Pediatrics, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 833, Taiwan.

Children (Basel, Switzerland)
|September 28, 2024
PubMed

Insights

Lactoferrin (LF) may help detect early cardiovascular disease (CVD) in children with chronic kidney disease (CKD). Lower LF levels correlate with increased arterial stiffness and blood pressure abnormalities, suggesting LF

Area of Science:

  • Pediatric Nephrology
  • Cardiovascular Research
  • Biomarker Discovery

Background:

  • Children with chronic kidney disease (CKD) face a heightened risk of cardiovascular disease (CVD).
  • Subclinical CVD in pediatric CKD can be identified using carotid intima-media thickness (cIMT), ambulatory blood pressure monitoring (ABPM), and arterial stiffness indices.
  • Lactoferrin (LF), a glycoprotein in breast milk, is being investigated for its potential role and as a biomarker in various diseases.

Purpose of the Study:

  • To investigate the relationship between lactoferrin (LF) levels and cardiovascular (CV) risk markers in children with CKD.
  • To explore LF's potential as a biomarker for subclinical CVD in pediatric CKD.

Main Methods:

  • Study included 102 children diagnosed with CKD stages G1-G4.
  • Evaluated LF concentration in relation to CKD severity, causes, overweight/obesity, cIMT, arterial stiffness, and ABPM profiles.

Main Results:

  • LF concentration was not associated with CKD severity or cause but correlated positively with overweight/obesity.
  • Lower LF levels were linked to increased cIMT and arterial stiffness.
  • Sixty percent of children with CKD exhibited ABPM abnormalities, with low LF associated with nighttime hypertension and nocturnal non-dipping.

Conclusions:

  • Lactoferrin (LF) demonstrates potential as a biomarker for detecting subclinical cardiovascular disease (CVD) in pediatric chronic kidney disease (CKD).
  • Early detection using LF could facilitate timely interventions, improving long-term cardiovascular outcomes in children with CKD.
  • Further research is necessary to elucidate the underlying mechanisms connecting LF and cardiovascular health in pediatric CKD.
Abstract

Keywords:
ambulatory blood pressure monitoringbiomarkercardiovascular diseasechildrenchronic kidney diseasehypertensionlactoferrin

More Related Videos

Assessment of Vascular Function in Patients With Chronic Kidney Disease08:50

Assessment of Vascular Function in Patients With Chronic Kidney Disease

Published on: June 16, 2014

16.2K
Demonstrating a Linear Relationship Between Vascular Endothelial Growth Factor and Luteinizing Hormone in Kidney Cortex Extracts05:56

Demonstrating a Linear Relationship Between Vascular Endothelial Growth Factor and Luteinizing Hormone in Kidney Cortex Extracts

Published on: January 22, 2020

4.7K

Related Concept Videos

Chronic Kidney Disease II: Clinical Manifestations01:24

Chronic Kidney Disease II: Clinical Manifestations

Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
2
Chronic Kidney Disease IV: Nursing Management01:18

Chronic Kidney Disease IV: Nursing Management

Nursing management is essential for preventing complications, maintaining stability, and improving patients' quality of life in chronic kidney disease (CKD). By using a structured approach, nurses help slow CKD progression and support effective patient care​.1. Comprehensive patient assessmentEffective management begins with nurses reviewing the patient’s medical history, and identifying key risk factors like diabetes, hypertension, and nephrotoxic drug use. Nurses assess signs of...
2
Chronic Kidney Disease III: Interprofessional Care01:28

Chronic Kidney Disease III: Interprofessional Care

Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
2
Chronic Kidney Disease I: Introduction01:25

Chronic Kidney Disease I: Introduction

Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage kidney disease (ESKD). At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate...
2
Heart Failure VI: Adjunct Therapies01:22

Heart Failure VI: Adjunct Therapies

Additional therapies for treating patients with heart failure (HF) may include procedural interventions, supplemental oxygen, the management of sleep disorders, and nutritional therapy.Procedural InterventionsImplantable Cardioverter-Defibrillator: For patients at risk of life-threatening arrhythmias due to severe left ventricular dysfunction, an Implantable Cardioverter-Defibrillator (ICD) can detect and terminate these arrhythmias, preventing sudden cardiac death and improving survival rates.
5
Acute Kidney Injury IV: Diagnostic Studies and Prevention01:30

Acute Kidney Injury IV: Diagnostic Studies and Prevention

Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
8