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Related Concept Videos

Diabetic Retinopathy01:27

Diabetic Retinopathy

DefinitionDiabetic retinopathy is a microvascular complication of diabetes affecting the retinal blood vessels.Risk FactorsDiabetic retinopathy is present in almost all individuals with type 1 diabetes and more than 60% of those with type 2 diabetes after two decades of disease.The risk increases with poor glycemic control, hypertension, dyslipidemia, smoking, pregnancy, and puberty.Although cataracts and glaucoma are also more frequent in people with diabetes, retinopathy remains the leading...
Diabetic Neuropathy01:22

Diabetic Neuropathy

DefinitionDiabetic neuropathy is nerve damage caused by long-standing diabetes mellitus. It results directly from prolonged high blood sugar levels.PathophysiologyThe pathophysiology of diabetic neuropathy involves both metabolic and vascular disturbances triggered by chronic hyperglycemia.Metabolic injury: Elevated glucose levels activate the polyol pathway within nerve cells, leading to the accumulation of sorbitol and fructose. This increases oxidative stress, disrupts normal nerve...

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Antioxidant Effect in Diabetic Peripheral Neuropathy in Rat Model: A Systematic Review.

Noradliyanti Rusli1, Chen Fei Ng2, Suzana Makpol3

  • 1Department of Medicine, Faculty of Medicine, Universiti Kebangsaan Malaysia, Cheras 56000, Malaysia.

Antioxidants (Basel, Switzerland)
|September 28, 2024
PubMed
Summary

Antioxidants show promise in managing diabetic peripheral neuropathy (DPN) by targeting oxidative stress. This review suggests they may help reverse DPN effects and improve nerve function in rat models.

Keywords:
antioxidantsdiabetic peripheral neuropathysystematic reviews

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Area of Science:

  • Biomedical Science
  • Pharmacology
  • Neuroscience

Background:

  • Diabetic peripheral neuropathy (DPN) is a vascular complication of diabetes mellitus.
  • DPN progression is a concern despite glucose control, necessitating early interventions.
  • Oxidative stress is a key factor in DPN development and progression.

Purpose of the Study:

  • To systematically review evidence on antioxidant effects in DPN.
  • To elucidate the role of antioxidants in DPN progression using rat models.
  • To assess the therapeutic potential of antioxidants for DPN.

Main Methods:

  • Comprehensive literature search across Web of Science, EBSCOhost, and Scopus.
  • Data extraction and risk of bias assessment using SYRCLE's tool.
  • Systematic review conducted following PRISMA 2020 guidelines.

Main Results:

  • 1268 articles were screened, 101 full-text articles reviewed, and 33 analyzed.
  • Evidence suggests antioxidants target oxidative stress in DPN.
  • Antioxidants demonstrated potential in improving nerve function.

Conclusions:

  • Antioxidants play a crucial role in managing DPN.
  • Therapeutic strategies involving antioxidants may help reverse DPN effects.
  • Targeting oxidative stress with antioxidants offers a promising avenue for DPN intervention.