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Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells
Published on: May 30, 2025
175
Non-Coding RNAs and Innate Immune Responses in Cancer
Carlos Romero Díaz1, María Teresa Hernández-Huerta2, Laura Pérez-Campos Mayoral3
1Tecnológico Nacional de México/IT Oaxaca, Oaxaca 68030, Mexico.
Biomedicines
|September 28, 2024
Summary
Non-coding RNAs (ncRNAs) are key regulators of the innate immune system and cancer. Their shared properties with trained immunity offer new avenues for personalized cancer therapies targeting inflammation.
Area of Science:
- Immunology
- Molecular Biology
- Oncology
Background:
- Non-coding RNAs (ncRNAs) play crucial roles in gene regulation and innate immunity.
- Both ncRNAs and innate immunity are implicated in cancer development and progression.
- Understanding their interplay is vital for cancer research.
Purpose of the Study:
- To review major types of ncRNAs (siRNAs, miRNAs, piRNAs, lncRNAs).
- To focus on the roles of ncRNAs in cancer, innate immunity, and inflammation.
- To explore therapeutic potential arising from their interrelationships.
Main Methods:
- Literature review of ncRNAs, innate immunity, epigenetics, inflammation, and cancer.
- Analysis of shared properties between ncRNAs and trained immunity modulators.
- Synthesis of current knowledge on ncRNA functions in disease.
Main Results:
- ncRNAs are closely linked to innate immunity, epigenetics, chronic inflammation, and cancer.
- ncRNAs exhibit properties like inducibility, specificity, memory, and transfer, similar to trained immunity.
- Significant interrelationships exist between ncRNAs, innate immunity, and inflammation pathways.
Conclusions:
- The intricate relationship between ncRNAs and innate immunity is central to cancer biology.
- ncRNAs' roles in inflammation and trained immunity suggest novel therapeutic targets.
- Combining ncRNA modulation with inflammation control may lead to personalized cancer treatments.
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