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Related Concept Videos

Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT01:25

Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT

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Calcium-Scoring CT ScanA calcium-scoring CT scan, also known as coronary artery calcium (CAC) scan, detects calcium deposits in the coronary arteries. This test assesses the risk of coronary artery disease (CAD), which can lead to cardiovascular events such as angina, heart failure, and sudden cardiac arrest.A calcium-scoring CT scan is generally recommended for individuals at intermediate risk of CAD without symptoms. It includes:Men aged 40-75 and women aged 50-75: Especially those with a...
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Related Experiment Video

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In Vitro Models of Cardiovascular Calcification.

Andrea Tóth1, Enikő Balogh1, Viktória Jeney1

  • 1MTA-DE Lendület Vascular Pathophysiology Research Group, Research Centre for Molecular Medicine, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary.

Biomedicines
|September 28, 2024
PubMed
Summary

Cardiovascular calcification, a key factor in heart disease, involves mineral buildup in arteries and valves. This review details how cell and tissue models advance research into cardiovascular calcification causes and treatments.

Keywords:
calcification detectioncalcification inducersvalve calcificationvalve interstitial cell calcificationvascular calcificationvascular smooth muscle cell calcification

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Area of Science:

  • Cardiovascular Biology
  • Biomineralization Research
  • Translational Medicine

Background:

  • Cardiovascular calcification, marked by hydroxyapatite deposition, elevates morbidity and mortality.
  • It's linked to aging and chronic conditions like CKD, diabetes, dyslipidemia, and hypertension.
  • Current treatments for cardiovascular calcification are lacking.

Purpose of the Study:

  • To review in vitro cell culture and ex vivo tissue models used in cardiovascular calcification research.
  • To highlight the contribution of these models to understanding calcification mechanisms.
  • To provide an overview of models for studying cardiovascular calcification.

Main Methods:

  • In vitro cellular models for studying cardiovascular calcification.
  • Ex vivo tissue culture models for cardiovascular calcification research.
  • Literature review of models applied in cardiovascular calcification studies.

Main Results:

  • Cellular and tissue models are essential tools in cardiovascular calcification research.
  • These models have facilitated discoveries of calcification inducers, inhibitors, and molecular pathways.
  • The review summarizes the application of various models in the field.

Conclusions:

  • In vitro and ex vivo models are crucial for advancing cardiovascular calcification research.
  • These models aid in understanding the complex pathophysiology of cardiovascular calcification.
  • Further research using these models is vital for developing therapeutic strategies.