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Mechanisms of Senescence and Anti-Senescence Strategies in the Skin

Evangelia Konstantinou1, Eliane Longange1, Gürkan Kaya1,2

  • 1Department of Medicine, University of Geneva, Rue Michel-Servet 1, CH-1206 Geneva, Switzerland.

Biology
|September 28, 2024
PubMed

Insights

Skin aging is driven by stressors and accumulating senescent cells. This review explores skin aging factors, senescence study methods, and therapies to eliminate harmful senescent cells for healthier skin.

Area of Science:

  • Dermatology
  • Gerontology
  • Cell Biology

Background:

  • The skin serves as a vital protective barrier against environmental insults.
  • Skin aging is influenced by various internal and external stressors.
  • Accumulation of senescent cells in the skin contributes to aging and age-related diseases.

Purpose of the Study:

  • To review factors contributing to skin aging and cellular senescence.
  • To discuss methodologies for studying senescence in vitro and in vivo.
  • To explore therapeutic strategies for eliminating senescent cells.

Main Methods:

  • Literature review of factors causing skin aging.
  • Analysis of in vitro and in vivo senescence research methods.
  • Examination of senolytics and senomorphic agents.

Main Results:

  • Identified key stressors and biological pathways implicated in skin aging.
  • Detailed methods for detecting and analyzing senescent cells.
  • Highlighted the detrimental effects of chronic senescent cell accumulation.

Conclusions:

  • Understanding skin aging and senescence is crucial for developing effective interventions.
  • Targeting senescent cells offers a promising therapeutic avenue for age-related skin conditions.
  • Further research into senotherapeutics can improve skin healthspan.
Keywords:
SASPcellular senescencep16INK4asenolyticssenomorphicssenotherapyskin aging

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