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3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
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Migraine and Stroke: A Scoping Review

Neal Nathan1, Angeline Ngo1, Suzan Khoromi1

  • 1Department of Neurosciences, University of California-San Diego, 200 W Arbor Drive, San Diego, CA 92103, USA.

Journal of Clinical Medicine
|September 28, 2024
PubMed

Insights

Migraine with aura (MA) increases ischemic stroke risk, though underlying causes are unclear. Research explores neurovascular pathology and biomarkers to understand this link and improve treatments.

Area of Science:

  • Neurology
  • Vascular Medicine
  • Epidemiology

Background:

  • Migraine with aura (MA) is linked to a higher risk of ischemic stroke.
  • The exact pathophysiology connecting MA and ischemic stroke remains poorly understood.
  • Potential mechanisms include cortical spreading depression (CSD) and neurovascular pathology.

Purpose of the Study:

  • To review and update the clinical connections between migraine and stroke.
  • To characterize the risk factors and pathophysiology linking MA and ischemic stroke.
  • To explore the role of biomarkers in understanding these vascular connections.

Main Methods:

  • Scoping review of the PubMed database.
  • Analysis of existing literature on migraine and stroke associations.
  • Examination of proposed pathophysiological mechanisms and risk factors.

Main Results:

  • Consistent evidence shows increased ischemic stroke risk in MA.
  • Various factors like CSD, neurovascular pathology, and genetic predisposition are implicated.
  • Distinctions between migrainous and non-migrainous infarctions are noted.
  • The association for migraines without aura (MO) and hemorrhagic stroke is less clear.

Conclusions:

  • Further research is needed to fully elucidate the pathophysiology of stroke risk in migraineurs.
  • Biomarker research holds promise for identifying vascular links and guiding treatment development.
  • Understanding the migraine-stroke connection is crucial for clinical management and prevention strategies.
Keywords:
cortical spreading depressionmigrainemigrainous infarctionstroke

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