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Related Concept Videos

Imaging Biological Samples with Optical Microscopy01:18

Imaging Biological Samples with Optical Microscopy

Optical microscopy uses optic principles to provide detailed images of samples. Antonie van Leeuwenhoek designed the first compound optical microscope in the 17th century to visualize blood cells, bacteria, and yeast cells. In 1830, Joseph Jackson Lister created an essentially modern light microscope. The 20th century saw the development of microscopes with enhanced magnification and resolution.
In optical microscopy, the specimen to be viewed is placed on a glass slide and clipped on the stage...
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Phase-Contrast Microscopes
In-phase-contrast microscopes, interference between light directly passing through a cell and light refracted by cellular components is used to create high-contrast, high-resolution images without staining. It is the oldest and simplest type of microscope that creates an image by altering the wavelengths of light rays passing through the specimen. Altered wavelength paths are created using an annular stop in the condenser. The annular stop produces a hollow cone of...

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Related Experiment Video

Updated: Jun 19, 2026

Doppler Optical Coherence Tomography of Retinal Circulation
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Single-Shot Ultra-Widefield Polarization-Diversity Optical Coherence Tomography for Assessing Retinal and Choroidal

Tiffany Tse1, Hoyoung Jung2, Mohammad Shahidul Islam1

  • 1School of Biomedical Engineering, Faculty of Medicine and Applied Science, University of British Columbia, Vancouver, BC V6T 1Z3, Canada.

Journal of Clinical Medicine
|September 28, 2024
PubMed
Summary

Ultra-widefield polarization-diversity OCT (UWF PD-OCT) offers enhanced molecular contrast for retinal imaging. This advanced optical coherence tomography system improves visualization of peripheral retinal abnormalities and pigmentary changes.

Keywords:
ophthalmologyoptical coherence tomographypolarizationretinal diseasesretinal imagingwide-field OCT

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Area of Science:

  • Ophthalmology
  • Biomedical Engineering
  • Medical Imaging

Background:

  • Optical coherence tomography (OCT) provides high-resolution imaging but has limitations in field-of-view and molecular specificity.
  • Conventional OCT relies on scattering contrast, hindering the detection of certain pathological features.

Purpose of the Study:

  • To develop and evaluate a custom 105° ultra-widefield polarization-diversity OCT (UWF PD-OCT) system.
  • To assess the diagnostic capabilities of UWF PD-OCT for retinal and choroidal conditions, especially peripheral abnormalities.

Main Methods:

  • Development of a custom 105° ultra-widefield polarization-diversity OCT (UWF PD-OCT) system.
  • Imaging of patients with peripheral lesions and pigmentary changes using UWF PD-OCT.
  • Comparative analysis with conventional OCT and other clinical imaging modalities.

Main Results:

  • UWF PD-OCT demonstrated enhanced detection of disease-specific features through molecular contrast, particularly in the peripheral retina.
  • The system effectively captured melanin distribution and pigmentary changes in a single imaging session.
  • Improved visualization facilitated precise monitoring of disease progression and provided deeper insights into pathologies.

Conclusions:

  • UWF PD-OCT represents a significant advancement in ocular imaging, offering comprehensive views of retinal pathologies.
  • The technology enhances the diagnosis and management of retinal and choroidal diseases by revealing peripheral abnormalities and melanin-specific changes.
  • Early detection and timely intervention are facilitated by the unique insights provided by UWF PD-OCT.