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Significance of Programmed Cell Death Pathways in Neurodegenerative Diseases.
Dong Guo1,2, Zhihao Liu1,2, Jinglin Zhou1,2
1College of Life Science, Fujian Normal University Qishan Campus, Fuzhou 350117, China.
International Journal of Molecular Sciences
|September 28, 2024
Summary
Programmed cell death (PCD) regulates neuronal development but its dysregulation drives neurodegeneration. This review explores PCD types and their role in diseases like Alzheimer's and Parkinson's.
Area of Science:
- Neuroscience
- Cell Biology
- Pathology
Background:
- Programmed cell death (PCD), also known as regulated cell death (RCD), is crucial for normal development.
- Dysregulation of PCD signaling contributes to neuronal loss and neurodegenerative diseases.
Purpose of the Study:
- To review the molecular mechanisms of various PCD modalities.
- To examine the role of PCD in the pathogenesis of major neurodegenerative diseases.
- To discuss therapeutic strategies targeting PCD.
Main Methods:
- Literature review of PCD modalities (apoptosis, necroptosis, pyroptosis, ferroptosis, cuproptosis).
- Analysis of PCD's impact on neurodegenerative disease progression (AD, PD, HD, ALS, MS, TBI, stroke).
- Examination of key signaling factors and therapeutic targets.
Main Results:
- Different PCD forms have distinct molecular pathways.
- Aberrant PCD contributes to neuronal damage in various neurological disorders.
- Specific PCD pathways present potential therapeutic targets.
Conclusions:
- Understanding diverse PCD mechanisms is key to treating neurodegenerative diseases.
- Targeting PCD offers a promising therapeutic avenue for neurological conditions.
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