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Colloidal precipitates01:09

Colloidal precipitates

The high insolubility of some precipitates can result in an unfavorable relative supersaturation. This can lead to colloidal particles with a large surface-to-mass ratio, where adsorption is promoted. For instance, in the precipitation of silver chloride, silver ions are adsorbed on the surface of the colloidal particles, forming a primary layer. This layer attracts ions of opposite charge (such as nitrate ions), forming a diffuse secondary layer of adsorbed ions. This electric double layer...
Coagulation01:06

Coagulation

Colloidal solids are solid particles suspended in solution. They are usually negatively charged, attracting a compact primary layer of positively charged ions, which attract more counterions to form an electrical double layer. Electrostatic repulsion between the charged double layers prevents the particles from colliding, stabilizing the colloids. These solids are often undesirable because they can contain toxins that are difficult to remove. Coagulation is a technique that helps aggregate and...
The Colloidal State01:29

The Colloidal State

The formation of a colloidal system is exemplified by an aqueous solution containing Cl− ions is introduced to another containing Ag+ ions, resulting in the precipitation of solid AgCl as extremely tiny crystals. Instead of settling out as a filterable precipitate, these crystals remain suspended in the liquid, showcasing a colloidal system.A colloidal system involves colloidal particles within the approximate range of 1 to 1000 nm in at least one dimension, dispersed in a medium called the...
Conservation of Mass in Finite Cotrol Volume01:16

Conservation of Mass in Finite Cotrol Volume

The principle of conservation of mass is a fundamental law in fluid mechanics and is applied using the continuity equation. We apply the concept to a finite control volume to derive the continuity equation.
A system is defined as a collection of unchanging contents, and the conservation of mass states that a system's mass is constant.
Conservation of Mass in Moving, Nondeforming Control Volume01:14

Conservation of Mass in Moving, Nondeforming Control Volume

Stormwater detention basins are essential in managing runoff during heavy rainfall, particularly in urban areas where impervious surfaces increase the risk of flooding. Understanding the conservation of mass in these systems allows engineers to optimize basin performance, balancing inflow, outflow, and water storage.
In the context of a detention basin, the conservation of mass states that the total mass of water entering the basin must equal the mass leaving the basin plus any accumulation of...
Couette Flow01:22

Couette Flow

Couette flow represents the flow of fluid between two parallel plates, with one plate fixed and the other moving with a constant velocity. This configuration allows for a simplified analysis using the Navier-Stokes equations, which govern fluid motion under conditions of viscosity and incompressibility. For Couette flow, the assumptions include a steady, laminar, incompressible flow with a zero-pressure gradient in the flow direction. This flow type is beneficial for understanding shear-driven...

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Related Experiment Video

Updated: Jun 25, 2026

A Microfluidic-based Hydrodynamic Trap for Single Particles
10:13

A Microfluidic-based Hydrodynamic Trap for Single Particles

Published on: January 21, 2011

16.6K

Offsetting Dense Particle Sedimentation in Microfluidic Systems.

Tochukwu Dubem Anyaduba1, Jesus Rodriguez-Manzano1

  • 1Department of Infectious Disease, Faculty of Medicine, Imperial College London, London W12 0HS, UK.

Micromachines
|September 28, 2024
PubMed
Summary
This summary is machine-generated.

Two novel methods combat microparticle sedimentation in microsystems. These techniques, a hydrodynamic solution and induced hindered settling, significantly reduce particle settling, improving biotechnological applications and microfluidic device design.

Keywords:
Richardson–ZakiStokes lawbeadscloud pointdense particlesdroplet microfluidicsfluid dynamicsfluid meteringfluid splittinghindered settlingmicrofluidicsphase changesedimentationsurfactant

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Area of Science:

  • Biotechnology
  • Microfluidics
  • Particle Science

Background:

  • Microparticle sedimentation complicates microsystem design, especially for delivery tools in biotechnology.
  • This phenomenon increases system footprint, cost, and complexity, particularly in particle metering and encapsulation.
  • Existing solutions like gel microparticles are often unsatisfactory.

Purpose of the Study:

  • To present two novel solutions to mitigate microparticle sedimentation in microsystems.
  • To improve the efficiency and reliability of microfluidic devices utilizing dense microparticles.
  • To offer alternatives to current methods for handling particle settling.

Main Methods:

  • A hydrodynamic solution altering particle trajectory against flow-rate dependent forces.
  • Induced hindered settling (i-HS) utilizing Richardson-Zaki (RZ) corrections of Stokes' law.
  • Validation via multi-well fluidic multiplexing and particle metering, and surfactant cloud point exploitation.

Main Results:

  • Hydrodynamic solution reduced well-to-well particle concentration variation from 45% to 17%.
  • Induced hindered settling (i-HS) achieved a 58% reduction in sedimentation rate by exploiting surfactant phase changes.
  • Both methods demonstrated effectiveness in minimizing particle sedimentation.

Conclusions:

  • The presented hydrodynamic and i-HS methods effectively eliminate or minimize bead settling in microsystems.
  • These solutions offer significant improvements for biotechnological applications and microfluidic device design.
  • The synergistic use of both methods provides enhanced control over particle behavior.