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An In vitro Model to Study Immune Responses of Human Peripheral Blood Mononuclear Cells to Human Respiratory Syncytial Virus Infection
Published on: December 10, 2013
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Adult Respiratory Syncytial Virus Infection: Defining Incidence, Risk Factors for Hospitalization, and Poor Outcomes,
Tal Brosh-Nissimov1,2, Daniel Ostrovsky1,3, Amos Cahan1,2
1Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheba 84101, Israel.
Pathogens (Basel, Switzerland)
|September 28, 2024
Summary
Respiratory syncytial virus (RSV) significantly hospitalizes adults, especially the elderly. Pulmonary and cardiovascular diseases increase hospitalization risk, while certain blood conditions worsen outcomes.
Area of Science:
- Epidemiology
- Infectious Diseases
- Public Health
Background:
- Respiratory syncytial virus (RSV) is a major cause of adult illness, particularly in the elderly and immunocompromised.
- Understanding RSV's impact on adult hospitalizations is crucial for public health strategies.
Purpose of the Study:
- To determine the incidence of RSV hospitalizations in adults.
- To identify risk factors associated with RSV hospitalization and adverse outcomes.
Main Methods:
- Retrospective cohort study utilizing data from two hospitals in southern Israel (2016-2022).
- Incidence rates of RSV and influenza hospitalizations were calculated.
- Poisson regression analysis identified risk factors for hospitalization and poor outcomes.
Main Results:
- The median annual RSV hospitalization incidence was 28.2/100,000, rising to 199/100,000 in adults aged 75 and older.
- Pulmonary diseases (RR 4.2), cardiovascular diseases (RR 3.3), and chronic renal failure (RR 2.9) were significant risk factors for hospitalization.
- 13.9% of hospitalized RSV patients experienced poor outcomes, with renal failure, neutropenia, neutrophilia, and lymphopenia being associated factors.
Conclusions:
- RSV imposes a substantial hospitalization burden on adults, with older individuals and those with comorbidities being most vulnerable.
- Identifying high-risk populations is essential for developing targeted prevention and treatment strategies, including vaccination.
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