Recent Advancements in Gallic Acid-Based Drug Delivery: Applications, Clinical Trials, and Future Directions

Area of Science:

• Pharmacology and Drug Delivery
• Natural Products Chemistry
• Biotechnology

Background:

• Gallic acid (GA) is a bioactive compound found in various foods and herbs with significant pharmacological properties.
• GA exhibits antioxidant, anti-inflammatory, and antineoplastic activities, among others.
• Despite its benefits, GA suffers from low permeability and bioavailability, limiting its therapeutic application.

Purpose of the Study:

• To review novel drug delivery systems for Gallic Acid (GA).
• To highlight recent advancements in nanocarrier-based delivery of GA.
• To discuss patents and clinical updates related to GA drug delivery.

Main Methods:

• Literature search conducted on Scopus, PubMed, ScienceDirect, and Google Scholar.
• Focus on recent research concerning nanocarrier systems for GA.
• Analysis of patents and clinical trial information.

Main Results:

• Numerous nanocarrier systems have been developed for GA, including liposomes, nanoparticles, and micelles.
• These systems aim to improve GA's physical and chemical stability and bioavailability.
• A range of nanocarrier formulations are detailed, addressing GA's BCS Class III characteristics.

Conclusions:

• Nanocarrier systems offer a promising approach to overcome the bioavailability limitations of Gallic Acid.
• Continued research and development in this area are crucial for realizing GA's full therapeutic potential.
• Emerging patents and clinical data indicate growing interest and progress in GA drug delivery.