Related Experiment Video
Updated: Jun 11, 2025
09:36
Unbiased Deep Sequencing of RNA Viruses from Clinical Samples
Published on: July 2, 2016
16.9K
SCANellome V2: Update of the Primate Anellovirus Reference Sequences Database
Florian Laubscher1, Laurent Kaiser1,2,3, Samuel Cordey1
1Laboratory of Virology, Department of Diagnostics, Geneva University Hospitals & Faculty of Medicine, University of Geneva, 1205 Geneva, Switzerland.
Viruses
|September 28, 2024
Summary
Anelloviruses, common in humans, show vast diversity. The updated SCANellome tool now identifies over 200 potential new species, enhancing analysis of primate anellovirus composition.
Area of Science:
- Virology
- Bioinformatics
- Genomics
Background:
- Anelloviruses are ubiquitous in humans and a significant part of the human virome.
- Torque teno virus (Alphatorquevirus genus) is a well-known anellovirus and a potential immunity biomarker.
- Metagenomic studies reveal extensive genomic diversity and frequent co-detection of anellovirus genera, genotypes, and species in humans.
Purpose of the Study:
- To update and enhance SCANellome, a tool for analyzing primate anellovirus composition.
- To incorporate new reference sequences and identify novel anellovirus species.
- To provide interactive phylogenetic analysis and update Anelloviridae taxonomy.
Main Methods:
- Updated SCANellome database with >900 new GenBank sequences.
- Generated 134 new representative sequences using 90% identity clustering.
- Performed phylogenetic analysis of ORF1 for new potential species.
- Updated Anelloviridae taxonomy to binomial nomenclature.
Main Results:
- Identified 206 potential new anellovirus species, including four from non-human primates.
- Added four new non-human primate species for potential ICTV proposal.
- SCANellome V2 offers interactive phylogenetic analysis across 12 primate genera.
- Anelloviridae taxonomy updated to binomial species naming.
Conclusions:
- The updated SCANellome tool significantly expands the identification of primate anelloviruses.
- This advancement aids in understanding anellovirus diversity and evolution in primates.
- The tool and taxonomic updates support ongoing research in virology and host-pathogen interactions.
