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Related Experiment Video

Updated: Jun 5, 2026

Accessing Early Differentiation of Virus-Specific Follicular Helper CD4+ T Cell in Acute LCMV-Infected Mice
05:03

Accessing Early Differentiation of Virus-Specific Follicular Helper CD4+ T Cell in Acute LCMV-Infected Mice

Published on: April 26, 2024

Does early letermovir initiation delay engraftment?

Léna Royston1, Catia Vieira Gomes1, Ming Zou2

  • 1Division of Infectious Diseases, University Hospital of Geneva, Geneva, Switzerland.

Antimicrobial Agents and Chemotherapy
|June 4, 2026
PubMed
Summary
This summary is machine-generated.

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Pretransplant CMV-IgG Titers and DNAemia Are Associated With CMV Infections Post Allogeneic Hematopoietic Cell Transplant With or Without Letermovir.

Open forum infectious diseases·2026

Letermovir prophylaxis reduced cytomegalovirus (CMV) infections but delayed engraftment in allogeneic hematopoietic cell transplantation recipients (allo-HCTR). Further vigilance is needed despite improved survival rates in these CMV-positive patients.

Area of Science:

  • Hematology
  • Infectious Diseases
  • Transplantation Medicine

Background:

  • Cytomegalovirus (CMV) infections pose a significant risk in allogeneic hematopoietic cell transplantation recipients (allo-HCTR).
  • Letermovir prophylaxis has shown efficacy in reducing CMV infections post-transplant.

Purpose of the Study:

  • To investigate the broader impact of letermovir prophylaxis on hematological outcomes in CMV-seropositive allo-HCTR.
  • To compare engraftment and survival rates between the pre-letermovir and letermovir eras.

Main Methods:

  • Retrospective analysis of 314 CMV-seropositive allo-HCTR.
  • Comparison of hematological outcomes, including engraftment time, between patients from the pre-letermovir and letermovir prophylaxis periods.
  • Literature review to identify similar trends.
Keywords:
antiviralcmvcytomegalovirusengraftmenthematopoietic cell transplantationletermovirside effect

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Last Updated: Jun 5, 2026

Accessing Early Differentiation of Virus-Specific Follicular Helper CD4+ T Cell in Acute LCMV-Infected Mice
05:03

Accessing Early Differentiation of Virus-Specific Follicular Helper CD4+ T Cell in Acute LCMV-Infected Mice

Published on: April 26, 2024

Generation of Multivirus-specific T Cells to Prevent/treat Viral Infections after Allogeneic Hematopoietic Stem Cell Transplant
08:52

Generation of Multivirus-specific T Cells to Prevent/treat Viral Infections after Allogeneic Hematopoietic Stem Cell Transplant

Published on: May 27, 2011

Retroviral Scanning: Mapping MLV Integration Sites to Define Cell-specific Regulatory Regions
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Main Results:

  • Delayed engraftment was observed in allo-HCTR+ patients during the letermovir period, even after adjusting for confounders.
  • Improved survival rates were noted in the letermovir period despite delayed engraftment.
  • Literature review corroborated the trend of delayed engraftment.

Conclusions:

  • Letermovir prophylaxis, while effective against CMV, may be associated with delayed hematological engraftment in allo-HCTR+.
  • Increased vigilance is warranted regarding potential adverse effects on engraftment.
  • Further research is needed to understand the mechanisms behind this observation.