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Updated: Jun 11, 2025

Techniques to Induce and Quantify Cellular Senescence
06:51

Techniques to Induce and Quantify Cellular Senescence

Published on: May 1, 2017

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Genetic origins, regulators, and biomarkers of cellular senescence

Grasiela Torres1, Ivan A Salladay-Perez1, Anika Dhingra2

  • 1Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, Los Angeles, CA, USA; Molecular Biology Interdepartmental Doctoral Program, University of California, Los Angeles, Los Angeles, CA, USA; Molecular Biology Institute, University of California, Los Angeles, Los Angeles, CA, USA.

Trends in Genetics : TIG
|September 28, 2024
PubMed

Insights

Cellular senescence, a key aging process, is driven by genetic factors and cellular stress. Understanding these mechanisms offers new therapeutic targets for age-related diseases.

Area of Science:

  • Molecular Biology
  • Genetics
  • Aging Research

Background:

  • Cellular senescence is a fundamental biological process implicated in aging and age-related diseases.
  • Multiple stressors, including genetic factors, trigger senescence.
  • Senescent cells (SnCs) accumulate with age and contribute to tissue dysfunction.

Purpose of the Study:

  • To comprehensively review the molecular biology and genetic origins of cellular senescence.
  • To explore the diverse cellular stressors and pathways that induce senescence.
  • To identify potential therapeutic targets for aging-related diseases by understanding senescence.

Main Methods:

  • Literature review of molecular biology and genetic studies on cellular senescence.
  • Analysis of pathways involved in senescence induction (e.g., telomere attrition, DNA damage, oncogene activation).
  • Examination of signaling and metabolic pathways interacting in senescence.

Main Results:

  • Senescence is initiated by various stressors like DNA damage, oncogene activation, and metabolic stress.
  • Genetic factors play a crucial role in driving senescence.
  • Complex signaling and metabolic pathways are intricately involved in the senescence process.

Conclusions:

  • Cellular senescence is a multifaceted process with significant genetic underpinnings.
  • Targeting senescent cells (SnCs) presents a promising therapeutic strategy for aging-related conditions.
  • Further research is needed to fully elucidate senescence biology and develop effective interventions.
Keywords:
SASPagingcellular senescence

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