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Neurogenesis and Regeneration of Nervous Tissue

Neurogenesis and Regeneration of Nervous Tissue

In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...

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Related Experiment Video

Updated: Jun 11, 2025

Preparation and Immunostaining of Myelinating Organotypic Cerebellar Slice Cultures

Preparation and Immunostaining of Myelinating Organotypic Cerebellar Slice Cultures

Published on: March 20, 2019

Feeding the wrath with myelin.

Sourav Ghosh¹, Carla V Rothlin²

¹Department of Neurology, Yale University School of Medicine, New Haven, CT 06520, USA; Department of Pharmacology, Yale University School of Medicine, New Haven, CT 06520, USA.

Trends in Immunology

|September 28, 2024

Summary

Researchers found that during glioblastoma recurrence after radiation therapy, macrophages provide lipids to mesenchymal tumor cells. This immune-cancer cell metabolic crosstalk fuels glioblastoma growth.

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Published on: March 26, 2015

Area of Science:

Oncology
Cancer Biology
Immunology

Background:

Glioblastoma (GBM) is an aggressive brain tumor with poor prognosis.
Understanding molecular and cellular changes during treatment and recurrence is crucial.
Distinct molecular subtypes of GBM influence disease progression and treatment response.

Purpose of the Study:

To investigate molecular and cellular alterations in glioblastoma during radiation therapy and disease recurrence.
To explore the role of immune-cancer cell interactions in GBM progression.
To characterize metabolic crosstalk between immune cells and tumor cells across GBM subtypes.

Main Methods:

Comparative analysis of molecular and cellular changes in glioblastoma.
Study of tumor microenvironment during radiation therapy and recurrence.
Investigation of metabolic pathways and cell-cell interactions.

Main Results:

A distinct metabolic crosstalk between immune cells (macrophages) and cancer cells was identified.
Macrophages consume cholesterol-rich myelin debris.
Lipids derived from myelin debris are supplied to mesenchymal-like tumor cells, promoting glioblastoma growth.

Conclusions:

Immune-cancer cell metabolic crosstalk is a key driver of glioblastoma growth, particularly during the transition to a mesenchymal-like state.
Macrophage-mediated lipid transfer fuels tumor progression post-radiation therapy.
Targeting this metabolic pathway may offer novel therapeutic strategies for glioblastoma.