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Reduced subthalamic and subthalamic-cortical coherences associated with the therapeutic carryover effect of
Lvpiao Zheng1, Ziling Luo1, Biswaranjan Mohanty1
1Department of Neurology, University of Minnesota, Minneapolis, MN, USA.
NPJ Parkinson'S Disease
|September 28, 2024
Abstract:
Coordinated reset deep brain stimulation (CR DBS), a promising treatment for Parkinson's disease (PD), is hypothesized to desynchronize neuronal populations. However, little in vivo data probes this hypothesis. In a parkinsonian nonhuman primate, we found that subthalamic CR DBS suppressed subthalamic and cortical-subthalamic coherences in the beta band, correlating with motor improvements. Our results support the desynchronizing mechanism of CR DBS and propose potential biomarkers for closed-loop CR DBS.
