Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Adrenal Gland Disorders01:27

Adrenal Gland Disorders

1.4K
Adrenal gland disorders manifest when the production of adrenal hormones deviates from the norm, resulting in either excessive or insufficient concentrations.
Adrenal insufficiency, characterized by insufficient cortisol and aldosterone production, leads to conditions like Addison's disease. This disorder, affecting the adrenal cortex, exhibits symptoms such as skin bronzing, dehydration, low blood pressure, fatigue, and weight loss. Congenital adrenal hyperplasia, a genetic ailment causing...
1.4K
Hormones of the Adrenal Glands01:31

Hormones of the Adrenal Glands

2.3K
Adrenal hormones play a pivotal role in maintaining the body's electrolyte balance and orchestrating responses to stress, showcasing the intricate functions of the adrenal cortex and medulla.
The adrenal cortex, a powerhouse of hormone synthesis, generates over two dozen corticosteroid hormones. The zona glomerulosa produces mineralocorticoids, exemplified by aldosterone, influencing the electrolyte composition of body fluids. The synthesis of glucocorticoids such as cortisol and...
2.3K
Hypothalamic-Pituitary Axis01:37

Hypothalamic-Pituitary Axis

59.6K
The response to stress—be it physical or psychological, acute or chronic—involves activation of the Hypothalamic-Pituitary-Adrenal (HPA) axis. The HPA axis is part of the neuroendocrine system because it involves both neuronal and hormonal communication. Its function is to regulate homeostatic systems—metabolic, cardiovascular, and immune—providing the necessary means to respond to a stressor.
59.6K
Adrenergic Receptors: β Subtype01:26

Adrenergic Receptors: β Subtype

1.5K
β-adrenoceptors have varied sensitivities towards adrenaline, noradrenaline, and isoprenaline. The order of agonist potency is as follows:
Isoprenaline > Adrenaline > Noradrenaline
Neurotransmitter binding to these receptors causes activation of adenylyl cyclase resulting in increased concentrations of cAMP and modulation of calcium ion channels within the cell. They are further classified into β1, β2, and β3 subtypes.
β1-adrenoceptors: β1-adrenoceptors...
1.5K
Anatomy of the Adrenal Glands01:17

Anatomy of the Adrenal Glands

2.0K
The adrenal or supra-renal glands, situated above the kidneys and aligned with the twelfth rib, are paired pyramid-shaped structures crucial for the body's stress response. During stress, these glands secrete hormones vital for adaptive physiological reactions.
These glands possess a distinctive yellow tinge due to the stored cholesterol and fatty acids required for hormone synthesis. They are encased in a fibrous capsule and cushioned by fat.
The adrenal gland comprises two distinct...
2.0K
Adrenergic Agonists: Therapeutic Uses01:30

Adrenergic Agonists: Therapeutic Uses

743
Adrenergic agonists have diverse therapeutic uses across various medical conditions and emergencies.
Emergency and Intensive Care Unit (ICU) applications: Pressor agents increase blood pressure, heart rate, and contractility in shock and organ failure situations. Dopamine can induce vasodilation and stimulate adrenoceptors. Endogenous catecholamines are effective in treating cardiogenic shock. α2-agonists like clonidine can reverse anesthesia-induced hypertension.
Allergies and...
743

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Continuous physiological monitoring for the detection of postoperative deterioration: a protocol for a multistage, multicentre, international, prospective cohort study.

BMJ open·2025
Same author

Natural genetic variation for fruit set rate within Malbec grapevine (Vitis vinifera L.) clones.

BMC plant biology·2025
Same author

Diploid genome assembly of the Malbec grapevine cultivar enables haplotype-aware analysis of transcriptomic differences underlying clonal phenotypic variation.

Horticulture research·2024
Same author

Prognostic indicators in dogs with intra-hepatic portal hypertension.

The Canadian veterinary journal = La revue veterinaire canadienne·2023
Same author

Cognitive Load Management: An Invaluable Tool for Safe and Effective Surgical Training.

Journal of surgical education·2023
Same author

Building communities of practice with social media.

The clinical teacher·2022

Related Experiment Video

Updated: Jun 11, 2025

Fecal Glucocorticoid Analysis: Non-invasive Adrenal Monitoring in Equids
08:02

Fecal Glucocorticoid Analysis: Non-invasive Adrenal Monitoring in Equids

Published on: April 25, 2016

9.6K

Comparison between typical primary and eunatraemic, eukalaemic hypoadrenocorticism: 92 cases.

Adrien Joaquim Da Silva1, Eilidh Gunn2, Pedro Jose Guzmán Ramos3

  • 1University College Dublin Veterinary Hospital, Dublin, Ireland. adrien.dasilva@ucdconnect.ie.

Irish Veterinary Journal
|September 28, 2024
PubMed
Summary

Hypoadrenocorticism in dogs can occur with or without electrolyte imbalances. Undetectable basal aldosterone levels strongly predict mineralocorticoid deficiency, and dogs with apparent glucocorticoid deficiency may progress to typical disease.

Keywords:
AldosteroneAtypicalCentralGlucocorticoidHypoadrenocorticism

More Related Videos

Primary Culture of Rat Adrenocortical Cells and Assays of Steroidogenic Functions
04:33

Primary Culture of Rat Adrenocortical Cells and Assays of Steroidogenic Functions

Published on: March 12, 2019

8.1K
A Novel Method: Super-selective Adrenal Venous Sampling
06:08

A Novel Method: Super-selective Adrenal Venous Sampling

Published on: September 15, 2017

23.3K

Related Experiment Videos

Last Updated: Jun 11, 2025

Fecal Glucocorticoid Analysis: Non-invasive Adrenal Monitoring in Equids
08:02

Fecal Glucocorticoid Analysis: Non-invasive Adrenal Monitoring in Equids

Published on: April 25, 2016

9.6K
Primary Culture of Rat Adrenocortical Cells and Assays of Steroidogenic Functions
04:33

Primary Culture of Rat Adrenocortical Cells and Assays of Steroidogenic Functions

Published on: March 12, 2019

8.1K
A Novel Method: Super-selective Adrenal Venous Sampling
06:08

A Novel Method: Super-selective Adrenal Venous Sampling

Published on: September 15, 2017

23.3K

Area of Science:

  • Veterinary Endocrinology
  • Canine Internal Medicine

Background:

  • Hypoadrenocorticism (Addison's disease) is an uncommon but serious endocrine disorder in dogs.
  • Some dogs present with only glucocorticoid deficiency, lacking typical electrolyte disturbances.

Purpose of the Study:

  • To compare dogs with hypoadrenocorticism with and without electrolyte disturbances.
  • To evaluate diagnostic markers for mineralocorticoid deficiency in canine hypoadrenocorticism.

Main Methods:

  • Retrospective observational study of 92 dogs diagnosed with hypoadrenocorticism.
  • Subdivision into groups based on the presence (Group 1) or absence (Group 2) of electrolyte disturbances.
  • Analysis of clinical signs, clinicopathological data, and aldosterone concentrations.

Main Results:

  • Dogs with electrolyte disturbances (Group 1) were younger and more frequently presented with vomiting, hyperproteinaemia, increased urea, increased creatinine, and hyperphosphataemia.
  • Dogs without electrolyte disturbances (Group 2) were less likely to show these clinical and laboratory findings.
  • An undetectable basal aldosterone concentration was highly predictive (94.3%) of mineralocorticoid deficiency.

Conclusions:

  • Canine hypoadrenocorticism cases in Ireland resemble international findings.
  • Basal aldosterone measurement is a reliable indicator of mineralocorticoid deficiency.
  • Dogs initially presenting with apparent glucocorticoid deficiency require monitoring for disease progression.