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Related Experiment Video

Updated: Jun 11, 2025

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Interfering antibodies may contribute to elevated D-dimer: a case report.

Dorte B Zilstorff1, Thomas Steffen Hermann2, Christine Rasmussen1

  • 1Department of Clinical Biochemistry, Copenhagen University Hospital-Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark.

Journal of Medical Case Reports
|September 28, 2024
PubMed
Summary

Interfering antibodies can elevate D-dimer levels, mimicking thromboembolism. This study found that approximately one-third of elevated D-dimer in a patient was due to these interfering antibodies.

Keywords:
d-dimerCase reportHeterophilic antibodiesImmunoassayInterfering antibodies

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Area of Science:

  • Clinical Chemistry
  • Immunology
  • Hematology

Background:

  • Elevated D-dimer levels are common in patients experiencing thromboembolisms.
  • Investigated interfering antibodies as a potential cause for elevated D-dimer levels.

Observation:

  • A pregnant patient with a history of pulmonary embolism presented with persistently elevated D-dimer without clinical signs of thromboembolism.
  • D-dimer levels were measured using two assays, and tests for rheumatoid factor and antibody interference were performed.

Findings:

  • Two D-dimer assays yielded similar results.
  • An antibody depletion strategy indicated that approximately one-third of the elevated D-dimer levels were attributable to interfering antibodies.

Implications:

  • Identifies interfering antibodies as a potential contributor to elevated D-dimer in this patient.
  • Highlights the role of heterophilic interference in D-dimer elevation.
  • Provides an analytical method for determining antibody interference.