Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

13.2K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
13.2K
The JAK-STAT Signaling Pathway01:20

The JAK-STAT Signaling Pathway

8.7K
Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as  SH2...
8.7K
Autoimmune Disorders01:29

Autoimmune Disorders

394
Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
394
Causality in Epidemiology01:21

Causality in Epidemiology

331
Causality or causation is a fundamental concept in epidemiology, vital for understanding the relationships between various factors and health outcomes. Despite its importance, there's no single, universally accepted definition of causality within the discipline. Drawing from a systematic review, causality in epidemiology encompasses several definitions, including production, necessary and sufficient, sufficient-component, counterfactual, and probabilistic models. Each has its strengths and...
331
Lethal Alleles02:41

Lethal Alleles

15.3K
Agouti: A Lethal Allele
Lucien Cuénot discovered lethal alleles in 1905 while studying the inheritance of coat color in mice. The agouti gene is responsible for the color of the coat in mice. This gene codes for an agouti-signaling protein, which is responsible for melanin distribution in mammals. The wild-type allele gives rise to gray-brown coat color in mice, while the mutant allele gives rise to yellow coat color. In addition to coat color, the agouti gene is associated with the yellow...
15.3K
Pedigree Analysis01:35

Pedigree Analysis

84.1K
Overview
84.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Small-Gain-Based Plug-and-Play Distributed Control Framework for DC Microgrids With Decentralized Reconfiguration.

IEEE transactions on cybernetics·2026
Same author

Development of potent BChE/Nrf2 modulators for Alzheimer's disease treatment via dual suppression of ferroptosis.

European journal of medicinal chemistry·2026
Same author

High-level biosynthesis of gastrodin in engineered Escherichia coli.

Journal of biotechnology·2026
Same author

Accelerating Reaction Discovery through AI-HTE Integration: Nitrene-Mediated C-O Coupling as a Validated Case Study.

JACS Au·2026
Same author

Niraparib treatment patterns and outcomes in first-line maintenance therapy for ovarian cancer: The RENI-1 study.

Chinese medical journal·2026
Same author

Impact of Post-exposure Prophylaxis on Pre-exposure Prophylaxis Initiation Among Men Who Have Sex with Men: A Nested Case-control Study.

AIDS and behavior·2026

Related Experiment Video

Updated: Jun 11, 2025

Standardized Histomorphometric Evaluation of Osteoarthritis in a Surgical Mouse Model
07:32

Standardized Histomorphometric Evaluation of Osteoarthritis in a Surgical Mouse Model

Published on: May 6, 2020

12.0K

[Causality between atopic diseases and osteoarthritis:a Mendelian randomization study].

Ming-Chen Zhang1, An Lin1, Zhi-Cheng Sang2

  • 1Beijing University of Chinese Medicine, Beijing 100029, China.

Zhongguo Gu Shang = China Journal of Orthopaedics and Traumatology
|September 29, 2024
PubMed
Summary

Asthma increases osteoarthritis risk, while atopic dermatitis does not show a clear link. This study used Mendelian randomization to explore causal relationships between these conditions.

Keywords:
AsthmaAtopic dermatitisAtopic diseaseMendelian randomizationOsteoarthritis

More Related Videos

Software-Assisted Quantitative Measurement of Osteoarthritic Subchondral Bone Thickness
08:52

Software-Assisted Quantitative Measurement of Osteoarthritic Subchondral Bone Thickness

Published on: March 18, 2022

2.9K
Destabilization of the Medial Meniscus and Cartilage Scratch Murine Model of Accelerated Osteoarthritis
07:06

Destabilization of the Medial Meniscus and Cartilage Scratch Murine Model of Accelerated Osteoarthritis

Published on: July 6, 2022

4.3K

Related Experiment Videos

Last Updated: Jun 11, 2025

Standardized Histomorphometric Evaluation of Osteoarthritis in a Surgical Mouse Model
07:32

Standardized Histomorphometric Evaluation of Osteoarthritis in a Surgical Mouse Model

Published on: May 6, 2020

12.0K
Software-Assisted Quantitative Measurement of Osteoarthritic Subchondral Bone Thickness
08:52

Software-Assisted Quantitative Measurement of Osteoarthritic Subchondral Bone Thickness

Published on: March 18, 2022

2.9K
Destabilization of the Medial Meniscus and Cartilage Scratch Murine Model of Accelerated Osteoarthritis
07:06

Destabilization of the Medial Meniscus and Cartilage Scratch Murine Model of Accelerated Osteoarthritis

Published on: July 6, 2022

4.3K

Area of Science:

  • Genetics and immunology
  • Epidemiology
  • Rheumatology

Context:

  • Atopic diseases, including asthma and atopic dermatitis, are common inflammatory conditions.
  • Osteoarthritis (OA) is a prevalent degenerative joint disease with complex etiology.
  • Understanding potential links between inflammatory and degenerative diseases is crucial for public health.

Purpose:

  • To investigate the potential causal relationship between asthma and atopic dermatitis with osteoarthritis using Mendelian randomization (MR).
  • To differentiate the specific contributions of asthma versus atopic dermatitis to OA risk.
  • To control for confounding factors like body mass index and osteoporosis in the analysis.

Summary:

  • Mendelian randomization analysis revealed a significant positive causal effect of asthma on osteoarthritis (OR=1.41, P=0.02).
  • Multivariate MR, adjusting for BMI and osteoporosis, further supported a direct causal link between asthma and OA (OR=1.57, P=0.03).
  • No significant causal relationship was found between atopic dermatitis and osteoarthritis in both standard and multivariate MR analyses (P > 0.05).

Impact:

  • Findings suggest asthma is a risk factor for developing osteoarthritis.
  • The study indicates that atopic dermatitis is unlikely to be a direct cause of osteoarthritis.
  • Results highlight the importance of considering comorbid conditions in disease etiology and management.