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Ralstonia mannitolilytica infection in a tertiary care center: An outbreak report

Sabah Alshuhri1, Aeshah Alosaimi1, Khaled Alnafee2

  • 1Infection Control and Hospital Epidemiology, King Faisal Specialist Hospital & Research Centre, Riyadh, Saudi Arabia.

American Journal of Infection Control
|September 29, 2024
PubMed
Abstract

Insights

A Ralstonia mannitolilytica outbreak was identified, traced to contaminated sodium chloride solution. Prompt recall and control measures halted the infection spread, highlighting the need for strict manufacturer oversight.

Area of Science:

  • Infectious Diseases
  • Microbiology
  • Public Health

Background:

  • Describes a significant outbreak of Ralstonia mannitolilytica infection occurring over a one-year period.
  • Highlights the challenge of identifying and controlling hospital-acquired infections.

Purpose of the Study:

  • To investigate and determine the source of a Ralstonia mannitolilytica outbreak.
  • To implement effective infection control measures and prevent further spread.

Main Methods:

  • Conducted epidemiological investigations and infection control measures.
  • Utilized device isolation, environmental sampling, and pulsed-field gel electrophoresis (PFGE) typing.
  • Expanded investigation to all hospital areas based on initial findings.

Main Results:

  • Identified 36 cases of Ralstonia mannitolilytica infection, predominantly in adults and males.
  • Traced the outbreak source to a specific lot of contaminated sodium chloride solution.
  • Confirmed the effectiveness of the recall and control measures, with no new cases reported post-intervention.

Conclusions:

  • Emphasizes the critical need for regular monitoring of manufacturer compliance with safety regulations for medical solutions.
  • Suggests considering an extended incubation period for enhanced identification of R. mannitolilytica in future outbreaks.
Keywords:
Nosocomial infectionRalstoniaSodium chloride

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