Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Receptor-mediated Endocytosis

Receptor-mediated Endocytosis

Receptor-mediated endocytosis is when bulk amounts of specific molecules are imported into a cell after binding to cell surface receptors. The molecules bound to these receptors are taken into the cell through inward folding of the cell surface membrane, which is eventually pinched off into a vesicle within the cell. Structural proteins, such as clathrin, coat the budding vesicle.
Clathrin-Mediated Endocytosis of LDL
One well-characterized example of receptor-mediated endocytosis is the...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Potent and Receptor-Selective Germination Inhibitor for <i>Striga hermonthica</i>.

Precision chemistry·2026

Same author

Long-Range Signals Built upon Plant Structural Continuity.

Annual review of plant biology·2026

Same author

Mechanical Modeling of Whisker-Filled Dispersed Isotactic Polypropylene: Matrix-Dominated Yielding and Fracture Mechanisms.

Polymers·2026

Same author

Target-agnostic SAR mapping and immunological evaluation of (-)-FR252921 and analogs against primary human immune cells.

Chemical science·2026

Same author

Exogenous Lipoid Pneumonia Caused by E-Cigarette Use Following Exposure to Oil Spray and Waterproofing Spray: A Case Report.

Clinical case reports·2026

Same author

Methylviologen resistance in loss-of-function mutants of the polyamine transporter gene OsLAT5.

PloS one·2026

Search research articles

Related Experiment Video

Updated: Jun 11, 2025

Analyzing Cellular Internalization of Nanoparticles and Bacteria by Multi-spectral Imaging Flow Cytometry

Analyzing Cellular Internalization of Nanoparticles and Bacteria by Multi-spectral Imaging Flow Cytometry

Published on: June 8, 2012

Water-Soluble Aromatic Nanobelt with Unique Cellular Internalization.

Konstantin Günther^1,2, Hideya Kono¹, Hiroki Shudo¹

¹Department of Chemistry, Graduate School of Science, Nagoya University, Chikusa, Nagoya, 464-8602, Japan.

Angewandte Chemie (International Ed. in English)

|September 30, 2024

Summary

This summary is machine-generated.

Researchers synthesized a water-soluble aromatic nanobelt for cellular studies. Its unique belt shape influences its stop-and-go uptake dynamics in HeLa cells, offering insights into nanomaterial-cell interactions.

Keywords:

aromatic compounds bioimaging cycloparaphenylene late-stage functionalization nanobelt

More Related Videos

Native Cell Membrane Nanoparticles System for Membrane Protein-Protein Interaction Analysis

Native Cell Membrane Nanoparticles System for Membrane Protein-Protein Interaction Analysis

Published on: July 16, 2020

Solid Lipid Nanoparticles SLNs for Intracellular Targeting Applications

Solid Lipid Nanoparticles SLNs for Intracellular Targeting Applications

Published on: November 17, 2015

Related Experiment Videos

Last Updated: Jun 11, 2025

Analyzing Cellular Internalization of Nanoparticles and Bacteria by Multi-spectral Imaging Flow Cytometry

Analyzing Cellular Internalization of Nanoparticles and Bacteria by Multi-spectral Imaging Flow Cytometry

Published on: June 8, 2012

Native Cell Membrane Nanoparticles System for Membrane Protein-Protein Interaction Analysis

Native Cell Membrane Nanoparticles System for Membrane Protein-Protein Interaction Analysis

Published on: July 16, 2020

Solid Lipid Nanoparticles SLNs for Intracellular Targeting Applications

Solid Lipid Nanoparticles SLNs for Intracellular Targeting Applications

Published on: November 17, 2015

Area of Science:

Organic Chemistry
Nanotechnology
Cell Biology

Background:

Cycloparaphenylenes (CPPs) are molecular analogues of carbon nanotubes.
Functionalization of CPPs is key to tailoring their properties for specific applications.
Understanding nanoparticle cellular uptake is crucial for drug delivery and nanomedicine.

Purpose of the Study:

To synthesize a water-soluble aromatic nanobelt.
To investigate the cellular uptake behavior of this nanobelt in HeLa cells.
To elucidate the structure-property relationship governing the nanobelt's cellular interactions.

Main Methods:

Late-stage functionalization of methylene-bridged [6]cycloparaphenylene ([6]MCPP).
Copper-catalyzed azide-alkyne cycloaddition (CuAAC) for nanobelt synthesis.
Cell-imaging experiments using HeLa cells.
Theoretical studies to support experimental findings.

Main Results:

An easily accessible alkyne-functionalized nanobelt was synthesized in one step.
The synthesized nanobelt demonstrated unique stop-and-go cellular uptake dynamics in HeLa cells.
Control experiments and theoretical analysis confirmed that the nanobelt's unique structure dictates its cellular uptake behavior.

Conclusions:

A novel water-soluble aromatic nanobelt was successfully synthesized.
The nanobelt exhibits distinct cellular uptake kinetics attributed to its belt-like structure.
This study provides valuable insights into the interaction of structurally defined nanobelts with biological systems.