The Spectrum of Hypogonadism in Women From Basrah

Background Determining the causes of female hypogonadism is crucial for guiding management and preventing complications. This study aimed to categorize the causes of female hypogonadism in Basrah and identify its frequency. Methodology This retrospective single-center study analyzed 1,111 women diagnosed with hypogonadism between 2008 and 2024 and described its etiology in women less than 45 years old (before menopause). The study was conducted in the Faiha Specialized Diabetes, Endocrine and Metabolism Center in Basrah, southern Iraq. Cases were classified into hypogonadotropic hypogonadism and hypergonadotropic hypogonadism according to specific causes such as disorders of sex development or difference (DSDs). Results The most frequent etiology in the 1,111 patients was hypogonadotropic hypogonadism, documented in 844 (76%) cases; functional amenorrhea was predominant in 402 (47.63%) of them. Next were 218 (20%) cases of hypergonadotropic hypogonadism. DSDs were documented in a small percentage of female hypogonadism cases; in only 49 (4%) cases was congenital adrenal hyperplasia the most common (57.14%). Conclusions The results of this study provide useful clinical insights into the frequency of female hypogonadism in Basrah.