Severe contact dermatitis due to nitroglycerin patches

Area of Science:

• Dermatology
• Pharmacology

Background:

• Nitroglycerin patches are widely used for managing angina pectoris.
• Transdermal drug delivery systems offer a convenient route for systemic medication administration.

Observation:

• Two cases of severe contact dermatitis associated with nitroglycerin patch use are presented.
• Skin reactions included erythema, pruritus, and vesiculation at the application site.

Findings:

• Contact dermatitis is a significant potential adverse effect of nitroglycerin transdermal patches.
• The severity of the reaction necessitates careful patient monitoring and management.

Implications:

• Healthcare providers should counsel patients on proper nitroglycerin patch application, emphasizing daily site rotation.
• Prompt reporting of skin irritation is crucial for early diagnosis and intervention to mitigate dermatitis severity.