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Corrosion02:49

Corrosion

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The degradation of metals due to natural electrochemical processes is known as corrosion. Rust formation on iron, tarnishing of silver, and the blue-green patina that develops on copper are examples of corrosion. Corrosion involves the oxidation of metals. Sometimes it is protective, such as the oxidation of copper or aluminum, wherein a protective layer of metal oxide or its derivatives forms on the surface, protecting the underlying metal from further oxidation. In other cases, corrosion is...
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Zones of Protection01:16

Zones of Protection

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In power systems, the entire setup is divided into protective zones to isolate faults and protect the rest of the network. These zones include generators, transformers, buses, transmission lines, distribution lines, and motors. Each zone can be visualized as a separate room in a house, with each room protected by its own circuit breaker.
Protective zones are defined by closed dashed lines, containing one or more components. A key characteristic of these zones is the strategic placement of...
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The Unfolded Protein Response01:37

The Unfolded Protein Response

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The ER is the hub of protein synthesis in a cell. It has robust systems to quality control protein folding and also for degradation of terminally misfolded proteins. Under normal conditions, a small proportion of misfolded proteins that cannot be salvaged need to be transported to the cytoplasm by the ER-associated degradation or ERAD pathways. However, if the ERAD cannot handle the misfolded proteins, the cell activates the unfolded protein response or UPR to adjust the protein folding...
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Corrosion of Reinforcement01:27

Corrosion of Reinforcement

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The corrosion of steel reinforcement within concrete is a process influenced by the material's inherent properties and external factors. The high pH level of around 13, provided by calcium hydroxide present in concrete, initially protects the steel reinforcement by promoting the formation of a passive iron oxide layer on its surface.
However, over time and under certain conditions like carbonation, chloride ingress, and cracking this protective state can be compromised. Steel has areas with...
165
Resistance01:19

Resistance

4.4K
When a current moves through any conductor, the conductor causes some level of difficulty for the current to flow. The measure of that difficulty is known as the resistance of the material and is represented by R. Every material has its own resistance. In the case of conductors, heat is emitted whenever a current passes through them. Resistance depends on the resistivity of the material. Resistivity is a characteristic of the material used to fabricate electrical components, whereas the...
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Transformers01:26

Transformers

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A device that transforms voltages from one value to another using induction is called a transformer. A transformer consists of two separate coils, or windings, wrapped around the same soft iron core. However, they are electrically insulated from each other.
The iron core has a substantial relative permeability. Therefore, the magnetic field lines generated due to the current in one winding are almost entirely confined within the core, such that the same magnetic flux permeates each turn of both...
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Updated: Jun 11, 2025

Total Internal Reflection Absorption Spectroscopy TIRAS for the Detection of Solvated Electrons at a Plasma-liquid Interface
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Iron TAMs: The fallen protectors.

Lijuan Sun1, Mikala Egeblad1,2

  • 1Department of Cell Biology, School of Medicine, Johns Hopkins University, Baltimore, MD, USA.

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Summary
This summary is machine-generated.

Researchers identified iron-rich tumor-associated macrophages (iTAMs) that promote tumor growth. Heme metabolism in iTAMs degrades Bach1, altering gene expression and activating tumor-supportive signals via endothelin receptor B.

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Area of Science:

  • Immunology
  • Cancer Biology
  • Metabolism

Background:

  • Tumor-associated macrophages (TAMs) play complex roles in cancer.
  • Specific macrophage subsets may have distinct functions within the tumor microenvironment.

Purpose of the Study:

  • To define a novel subset of TAMs characterized by high iron content.
  • To elucidate the metabolic and signaling pathways governing the function of these iron-rich TAMs (iTAMs).

Main Methods:

  • Analysis of macrophage populations within tumors.
  • Investigation of heme metabolism and its downstream effects on gene expression.
  • Assessment of signaling pathways, including endothelin receptor B.

Main Results:

  • Identification and characterization of an "iron-rich" subset of TAMs (iTAMs).
  • Demonstration that heme metabolism in iTAMs leads to Bach1 degradation.
  • iTAMs exhibit a distinct transcriptional profile and activate tumor-supportive functions through endothelin receptor B.

Conclusions:

  • Iron metabolism significantly shapes the phenotype and function of TAMs.
  • iTAMs represent a pro-tumorigenic macrophage subset.
  • Targeting iTAMs or their signaling pathways may offer new therapeutic strategies in cancer treatment.