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Updated: Jun 11, 2025

Ultrasound-guided Botulinum Toxin-A Injections: A Method of Treating Sialorrhea
Published on: November 9, 2016
Consensus Recommendations for Treatment of the Upper Face With LetibotulinumtoxinA
Ho-Sung Choi1,2,3,4,5,6,7, Jimmy Wang1,2,3,4,5,6,7, Dahlia Tauber1,2,3,4,5,6,7
1Ho-Sung Choi, MD, is a cosmetic surgeon at the PIENA Aesthetic Medical Clinic, Seoul, Korea.
This study presents expert guidelines for using letibotulinumtoxinA to treat upper facial lines. The recommendations cover injection techniques, dosage, and site selection for forehead, glabellar, and lateral canthal lines.
Area of Science:
- Aesthetic Medicine
- Dermatology
- Cosmetic Procedures
Background:
- Facial lines, particularly on the upper face, are a common aesthetic concern.
- Botulinum toxin type A is a widely used treatment for dynamic facial wrinkles.
- Standardized guidelines are needed for optimal and safe application of newer formulations like letibotulinumtoxinA.
Purpose of the Study:
- To develop expert-driven clinical guidelines for the aesthetic treatment of upper facial lines using letibotulinumtoxinA.
- To provide recommendations on injection sites, dosage, and techniques for forehead horizontal lines, glabellar frown lines, and lateral canthal lines.
- To enhance the safety and efficacy of letibotulinumtoxinA treatments by considering relevant anatomy and patient factors.
Main Methods:
- Convened a panel of seven aesthetic experts from South Korea and Australia.
- Experts provided consensus-based recommendations for letibotulinumtoxinA treatment.
- Considered relevant facial anatomy, patient assessment, selection criteria, and complication minimization strategies.
Main Results:
- Developed specific recommendations for treating forehead horizontal lines, glabellar frown lines, and lateral canthal lines.
- Guidelines include details on optimal injection sites, appropriate dosage ranges, and precise injection techniques.
- Addressed patient selection and anatomical considerations to minimize potential adverse events.
Conclusions:
- The developed guidelines offer a standardized approach for practitioners treating upper facial lines with letibotulinumtoxinA.
- These recommendations aim to improve treatment outcomes, ensuring both safety and efficacy for aesthetic practitioners.
- The guidelines serve as a valuable resource for clinicians of all skill levels using letibotulinumtoxinA in aesthetic practice.
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